N-Phenylhydroxylamine 苯基羟胺

CAS 100-65-2 MFCD00045718

化学结构图

100-65-2
SMILES: ONC1CCCCC1

化学属性

Mol. FormulaC6H7NO
Mol. Weight109.13
Melting Point80-84 °C
Solubility溶于冷水、热水,易溶于醇、醚。

别名和识别编码

Chemical NameN-Phenylhydroxylamine
CAS Number100-65-2
Synonym Hydroxyaminobenzene 苯基羟胺 N-Hydroxyaniline NCI C-60093 N-Phenylhydroxyamine beta-Phenylhydroxylamine Aniline, N-hydroxy- Phenylhydroxyamine 苯胲 N-羥苯胺 NCI-C60093 Phenylhydroxylamine N-Phenylhydroxylamine N-HYDROXYANILINE N-苯胲 N-羟基苯胺 N-苯基羟胺 N-HYDROXYLANILINE N-Hydroxybenzenamine Benzenamine, N-hydroxy- Β-苯胲
MDL NumberMFCD00045718
EC Number202-875-6
Chemical Name Translation苯基羟胺
Wiswesser Line NotationQMR
Beilstein Registry Number0507174
PubChem Substance ID7518
LabNetwork Molecule IDLN00361415
InChIInChI=1S/C6H7NO/c8-7-6-4-2-1-3-5-6/h1-5,7-8H
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分类

  • {SNA} Building Blocks, Chemical Synthesis, Hydroxylamines, Nitrogen Compounds, Organic Building Blocks

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P301+P310
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
RTECSNC4900000
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
UN Number 2811
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 247 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 44(3),68,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 44(3),68,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Human
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Skin and Appendages - primary irritation (after topical exposure)
REFERENCE :
   AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.  (Leipzig,
   Ger. Dem. Rep.)  V.1-109, 1873-1925.  For publisher information, see NSAPCC.
    Volume(issue)/page/year: 35,401,1895

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVE

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   NTPTB* NTP Technical Bulletin.  (National Toxicology Program, Landow Bldg.
   3A-06, 7910 Woodmont Ave., Bethesda, MD 20205)  Volume(issue)/page/year:
   JAN1982

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2 umol/L
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 86,155,1995

其他信息

  • 稳定性:Unstable - deteriorates with storage. Incompatible with strong oxidizing agents.
  • 用途:用于有机合成。
  • MOL 文件:100-65-2.mol
  • Building Block for Synthesis
  • 外观性质:无色针状结晶。
  • 生产方法:将250g(4.7mol)硝基苯和8L水一起猛烈搅拌,于15-20min内分批加入620g(8.1mol)85%锌粉,还原反应中温度升至60-65℃,反应毕,趁热滤除氧化锌,滤液用食盐饱和(约需3kg食盐),冷至0℃,结晶出苯胲。得纯品275-300g,收率62-68%。

系列性分类


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