5-Chloropyridine-2,4-Diol 5-氯-2,4-二羟基吡啶

CAS 103766-25-2 MFCD08458352

化学结构图

103766-25-2
SMILES: O=c1cc(O)[nH]cc1Cl

化学属性

Mol. FormulaC5H4ClNO2
Mol. Weight145.54
Density1.422
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name5-Chloropyridine-2,4-Diol
CAS Number103766-25-2
Synonym 2(1H)-Pyridinone,5-chloro-4-hydroxy-(9CI) 5-Chloro-2,4-dihydroxypyridine 5-Chloro-2,4-pyridinediol 5-Chloro-4-hydroxy-2-pyridone 5-chloropyridine-2,4-diol CDHP GIMERACIL Gimeracil,(CDHP) Gimeracil; chlorodihydroxypyridine. Abbreviation: CDHP. gimestat （CDHP）Gimeracil
MDL NumberMFCD08458352
Reaxys-RN119489
Beilstein Registry Number119489
PubChem Substance ID87560206
EC Number250-023-7
Chemical Name Translation5-氯-2,4-二羟基吡啶
FormulaC5H4ClNO2
IUPAC Name5-chloro-2-hydroxypyridin-4(1H)-one
InChIKeyZPLQIPFOCGIIHV-UHFFFAOYSA-N
InChIInChI=1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)
Canonical SMILESO=C1C=C(O)NC=C1Cl
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Gimeracil is a pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

相关文献及参考

  • Shirasaka, T., et al.: Cancer Res., 56, 2602 (1996),
  • Patt, Y., et al.: J. Clin. Oncol., 22, 271 (2004),
  • Shirao, K., et al.: Cancer, 100, 2355 (2004),

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

其他信息

  • TCI Shanghai:4-羟基-5-氯-2-(1H)吡啶酮 5-Chloro-4-hydroxy-2(1H)-pyridinone,>;98.0%(LC)(T)(103766-25-2)

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Dehydrogenase

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