Glp-1(7-36) Amide 胰高血糖素样肽1(7-36)酰胺

CAS 107444-51-9 MFCD00133373

化学结构图

107444-51-9
SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC1=CNC=N1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2C=CC=CC1=2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O

化学属性

Mol. FormulaC149H226N40O45
Mol. Weight3297.63

别名和识别编码

Chemical NameGlp-1(7-36) Amide
Synonym Preproglucagon 78-107 Amide
MDL NumberMFCD00133373
CAS Number107444-51-9
PubChem Substance ID329799974
Chemical Name Translation胰高血糖素样肽1(7-36)酰胺
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分类

  • Cell Biology, Cell Signaling and Neuroscience, Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, GLP-1 Receptor Ligands, Gastrointestinal Peptides, Glucagon, Glucagon and Glucagon-Like Peptides, Glucagon-Like Pepti
  • {SNA} Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, GLP-1 Receptor Ligands, Gastrointestinal Peptides, Glucagon, Glucagon and Glucagon-Like Peptides, Glucagon-Like Peptides, Hormones, Obesity Peptides, Other Protein/Peptide Hormones, Peptides and Proteins, Peptides for Cell Biology, 细胞信号转导和神经科学, 细胞生物学,

相关文献及参考

  • [2]. Mentlein R, et al. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem. 1993 Jun 15;214(3):829-35.
  • [3]. Nauck MA, et al. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1993 Aug;36(8):741-4.
  • [4]. Hansen L, et al. Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology. 1999 Nov;140(11):5356-63.
  • Bell, G., et al., Exon duplication and divergence in the human preproglucagon gene. Nature 304 , 368-371 摘要
  • [1]. Kreymann
  • [1]. Kreymann B, et al. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet. 1987 Dec 5;2(8571):1300-4.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Other Protein/Peptide Hormones - Hormones
  7. Glucagon - Other Protein/Peptide Hormones
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Glucagon Receptor  (胰高血糖素受体)

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