m-Phenylenediamine 间苯二胺

CAS 108-45-2 MFCD00007799

化学结构图

108-45-2
SMILES: NC1CCCC(N)C1

化学属性

Mol. FormulaC6H8N2
Mol. Weight108.14
Boiling Point-
Melting Point60 - 66°C
Density1.139
Flash Point-
SolubilitySoluble in water, methanol, acetone, DMF, MEK, dioxane
TSCAYes
Autoignition Point1040 °F
Vapor Density3.7 (vs air)
Vapor Pressure0.62 mmHg ( 100 °C)
Stability对空气和光线敏感
Appearance pellets
Refractive index1.6339

别名和识别编码

Chemical Namem-Phenylenediamine
CAS Number108-45-2
Synonym 1,3-Phenylenediamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} M-phenylenediamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} M-phenylenediamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} M-phenylenediamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} M-phenylenediamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} M-phenylenediamine {} {} {} {} {} {} {} {}
EC Number203-584-7
Beilstein Registry Number471357
MDL Number-
PubChem Substance ID7935
Reaxys-RN471357
Merck Number7283
Chemical Name Translation间苯二胺
Wiswesser Line NotationZR CZ
LabNetwork Molecule IDLN00195516
InChIInChI=1S/C6H8N2/c7-5-2-1-3-6(8)4-5/h1-4H,7-8H2
Canonical SMILESNC1=CC=CC(N)=C1
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分类

  • {SA} Building Blocks, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks, Polyamines
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • Building Blocks, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks, Polyamines
  • {SNA} Building Blocks, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks, Polyamines

产品应用

  • 分光光度测定亚硝酸盐，检定溴酸盐、溴化物、铬酸盐、臭氧、金、铜、重铬酸盐、铁、氧和铂，测定活性氯、铬、铱、亚硝酸盐和钯。

相关文献及参考

  • Kano, K., et al.: Biochim. Biophys Acta, 509, 289
  • Short: II/27B
  • Merck:14,7283
  • Merck:14,7283 Beilstein: 13,IV,79
  • Short: II/3

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H301+H331
  • H301+H311+H331
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes 6.1 T,N
RTECSSS7700000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P350
  • P302+P352+P312+P362+P364
  • P304+P340+P311
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P311
  • P308+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P337+P313
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 1673
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Safety Statements
  • S1/2 None 上锁保管并避免儿童触及；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R36 Irritating to eyes 刺激眼睛
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R50/53
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Packing GroupIII
Hazard Class6.1
Warnings 危化品目录(2015) 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1485 mg/kg/47W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   KJMSAH Kyushu Journal of Medical Science.  (Fukuoka, Japan)  V.6-15,
   1955-64.  Discontinued.  Volume(issue)/page/year: 13,175,1962

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RBPMAZ Revue Belge de Pathologie et de Medecine Experimentale.  (Brussels,
   Belgium)  V.18-31, 1947-65.  For publisher information, see PTEUA6.
   Volume(issue)/page/year: 22,1,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KJMSAH Kyushu Journal of Medical Science.  (Fukuoka, Japan)  V.6-15,
   1955-64.  Discontinued.  Volume(issue)/page/year: 13,175,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 53(7),62,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 562 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   070944)  V.1-    1973-  Volume(issue)/page/year: 12,355,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 250 ug/plate
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 2(4),325,1983

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 175 ug/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,349,1991

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 50 ug/L
REFERENCE :
   NCIMAV National Cancer Institute, Monograph.  (U.S. Government Printing
   Office, Supt. of Documents, Washington, DC 20402)  No.1-    1959-
   Volume(issue)/page/year: 58,243,

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 12 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Sci

TYPE OF TEST            : Body fluid assay
TEST SYSTEM             : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION           : 240 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 138,137,1984

TYPE OF TEST            : Mutation

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 375 mg/kg
SEX/DURATION            : male 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   SheCW# Personal Communication from C.W. Sheu, Genetic Toxicology Branch,
   FDA, Mar. 25, 1977  Volume(issue)/page/year: 25MAR1977

Restrict 危险品

其他信息

  • 用途一:用作分析试剂、树脂固化剂和阻聚剂，也用于染料的合成
  • 常规方法:采用铁桶包装，每桶50kg。贮存时要防潮、防晒。为防止氧化，加入适量的还原剂。按有毒危险品规定贮运。
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 蒸气压:0.62 mm Hg ( 100 °C)
  • Alfa Aesar:间苯二胺,99+% m-Phenylenediamine, 99+%(108-45-2)
  • 蒸气密度:3.7 (vs air)
  • 用途三:偶氮染料和吖嗪染料的中间体，主要用于制造直接耐晒黑RN、碱性橙、碱性棕G、直接耐晒黑G等染料，并用作毛皮染料，在日本，偶氮染料消费的间苯二胺占总消费量的90%。也用作环氧树脂的固化剂、水泥的促凝剂，并用于
  • MSDS 信息:间苯二胺(108-45-2).msds
  • 类别:有毒物品
  • 急救措施:皮肤接触：立即脱去污染的衣着，用肥皂水及清水彻底冲洗。注意手、足和指甲等部位。 眼睛接触：立即提起眼睑，用大量流动清水或生理盐水冲洗。
  • MOL 文件:108-45-2.mol
  • 防护措施:呼吸系统防护：空气中浓度较高时，佩带防毒面具。紧急事态抢救或逃生时，应该佩戴自给式呼吸器。 眼睛防护：戴化学安全防护眼镜。 防护服：穿紧袖工作服，长统胶鞋。 手防护：戴橡皮手套。 其它：工作现场禁止吸烟、进食和饮水。及时换洗工作服。工作前后不饮酒，用温水洗澡。进行就业前和定期的体检。
  • 灭火剂:雾状水、二氧化碳、砂土
  • TCI Shanghai:1,3-苯二胺 1,3-Phenylenediamine,>;98.0%(GC)(T)(108-45-2)
  • 用途二:主要用作染料中间体及环氧树脂固化剂
  • 特性:108-45-2（间苯二胺）在空气中不稳定,通常以稳定的盐酸盐的形式存在，易变成淡红色。溶于乙醇、水、氯仿、丙酮、二甲基甲酰胺，微溶于醚、四氯化碳，难溶于苯、甲苯、丁醇。
  • 海关编码:29215119
  • 用途四:分光光度测定
  • 在空气中不稳定，易变成淡红色，易溶于乙醇、水、甲醇、氯仿、丙酮、二甲基甲酰胺、丁酮和二氧六环，微溶于乙醚、四氯化碳、异丙醇和苯耳甲酸二丁酯，极微溶于苯、甲苯、二甲苯和丁醇
  • 下游产品:间苯二酚 --> 1,3-二氯苯 --> 氟康唑 --> 碱性橙 2 --> 4-氨基-N,N-二甲基苯胺 --> 1,3-二氟苯 --> 2,4-二氟苯胺 --> 间氨基乙酰苯胺 --> 直接黑 FF --> 直接黑19 --> 弱酸性红棕 V --> 分散红 74 --> 直接黑 38 --> 直接耐晒黑G --> 碱性橙 --> 直接混纺棕D-RS --> 直接红棕R --> 活性嫩黄M-7G --> 酸性
  • Acros Organics:间苯二胺/mpd m-Phenylenediamine, 99+%(108-45-2)
  • {Che
  • 图谱信息:间苯二胺(108-45-2)红外图谱(IR1) 间苯二胺(108-45-2)核磁图( 13 CNMR) 间苯二胺(108-45-2)质谱(MS) 间苯
  • 上游原料:硫酸 --> 对二硝基苯
  • 泄漏应急处理:隔离泄漏污染区，周围设警告标志，建议应急处理人员戴好防毒面具，穿化学防护服。不要直接接触泄漏物，用清洁的铲子收集于干燥净洁有盖的容器中，运至废物处理场所或用沙土混合，逐渐倒入稀盐酸中(1体积浓盐酸加2体积水稀释)，放置24小时，然后废弃。如大量泄漏，收集回收或无害处理后废弃。
  • 急性毒性:口服-大鼠 LD50: 280 毫克/公斤; 口服-小鼠 LD50: 67.7 毫克/公斤
  • 方法一:硝基苯经混酸硝化成间、邻、对二硝基苯的混合物，再经亚硫酸钠和液碱精制得间二硝基苯，然后用铁粉还原或加氢还原制得间苯二胺。原料消耗定额：硝基苯1400kg/t、硝酸787kg/t、硫酸（98%）780kg/t、铁粉3083kg/t。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Polyamines - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Oximes