Piperidine 哌啶(易制毒)

CAS 110-89-4 MFCD00005979

化学结构图

110-89-4
SMILES: c1ccncc1

化学属性

Mol. FormulaC5H11N
Mol. Weight85.15
Refractive indexn20/D 1.452(lit.)
Boiling Point106 °C(lit.)
Density0.862 g/mL at 20 °C(lit.)
Melting Point-13 °C (lit.)
Flash Point3°(37°F)
TSCAYes
Vapor Density3 (vs air)
Vapor Pressure23 mmHg ( 20 °C)
SolubilityMISCIBLE

别名和识别编码

Chemical NamePiperidine
Synonym HEXAHYDROPYRIDINE 聚丙烯(无规共聚) Pentamethyleneimine AKOS BBS-00003659 六氢吡啶 hexahydropyridinepentamethyleneimine Hexazane azacyclohexane PENTAMETHYLENEIMINE Pyridine, hexahydro- Pentamethyleneamine Pentamethylenimine Cypentil 1-Oxa-4-azacyclohexane; Azacyclohexane; Cyclopentimine; Hexahydropyridine; Pentamethyleneimine PIP PIPERIDINE PPR hexahydro-pyridin 一氮六环 Cyclopentimine Piperidin 派盯 Ⅲ型聚丙烯 hexahydroazine Hexahydropyridine 一氮六圜 Pentamethylenimin {Chemica PIPERIDINE ON RASTA RESIN 哌啶
CAS Number110-89-4
PubChem Substance ID8082
EC Number203-813-0
Beilstein Registry Number102438
MDL NumberMFCD00005979
Merck Number14,7468
Chemical Name Translation哌啶(易制毒)
Wiswesser Line NotationT6MTJ
InChIInChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
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分类

  • {SNA} Building Blocks, C5 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Humulus lupulus (Hops), Nutrition Research, Phytochemicals by Plant (Food/Spice/Herb), Piperidines
  • {SNA} Acids & Bases, Bases, Building Blocks, C5 to C7, Chemical Synthesis,

相关文献及参考

  • Merck 14 ,7468
  • Beil. 20 ,V,2,3
  • Fieser 1 ,886 / Fieser 2 ,332 / Fieser 4 ,393 / Fieser 6 ,472 / Fieser 7 ,293
  • Aldrich MSDS 1 , 1500:B / Corp MSDS 1 (2), 2845:A / FT-IR 1 (1), 358:C / FT-IR 2 (1), 558:B / FT-NMR 1 (1), 563:B / IR-Spectra (2), 189:F / IR-Spectra (3), 210:G / NMR-Reference 2 (1), 314:A / RegBook 1 (1), 381:E / Sax 6 , 2236 / Sigma FT-IR 1 (2), 853:C / Structure Index 1 , 54:C:3
  • Base catalyst in the Doebner modification of the Knoevenagel condensation; see Malonic acid, A11526.
  • Widely used for cleavage of Fmoc protecting groups: J. Org. Chem., 52, 1197 (1987); Tetrahedron Lett., 34, 6135 (1993). See Appendix 6.
  • For preparation of the piperidine enamine of cyclooctanecarboxaldehyde, and its subsequent use in the synthesis of spirohexadienones, see: Org. Synth. Coll., 7, 473 (1990).

安全信息

GHS Symbol
WGK Germany1
Hazard Codes F,T F;T T,F
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H331 Toxic if inhaled 吸入中毒
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H311+H331
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSTM3500000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P304+P340+P310
  • P370+P378
  • P403+P235
  • P303+P361+P353
Signal word Danger
UN Number 2401 UN2401 UN 3286 3/PG 2
Risk Statements
  • R34 Causes burns 会导致灼伤
  • R23/24 Toxic by inhalation and in contact with skin 吸入及皮肤接触都有毒
  • R11 Highly flammable 非常易燃
  • R10 Flammable 易燃
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R52 Harmful to aquatic organisms 对水生生物有害
  • R24 Toxic in contact with skin 与皮肤接触有毒
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Storage condition Store in dark! Air Sensitive
Packing GroupI
Hazard Class8
Restrict 易制毒 {} 易制毒化学品
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPMRAB Japanese Journal of Medical Sciences, Part 4:  Pharmacology. (Tokyo,
   Japan)  V.1-16, 1926-43. For publisher information, see JJPAAZ.
   Volume(issue)/page/year: 7,128,1933

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 4(2-3),345,1980

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6000 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 15,116,1979

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 8020 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,155,1988

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 5050 umol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3 mg/m3/24H
SEX/DURATION            : female 4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 14,40,1975

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/m3/24H
SEX/DURATION            : female 4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 14,40,1975

其他信息

  • 下游产品:2-氯-6-甲基-3-吡啶甲腈 --> 6-溴-3-丁酰-2H-苯并吡喃-2-酮 --> 5-甲基-4-异恶唑磺酰氯 --> 2-氨基-5-硝基嘧啶 --> 米诺地尔 --> 四硫化双五亚甲基秋兰姆 --> 咳安定 --> 3-乙酰氨基香豆素 --> 6-氯-2-氧代-2H-苯并吡喃-3-羧酸 --> 芥子酸 --> 3-乙酰基-7-羟基-苯并吡喃-2-酮 --> 2,4,5-三甲氧基肉桂酸 --> 盐酸地芬尼多 --> 5-溴-2-氟肉桂酸 --> 4-乙氧基肉桂酸 --> 哌啶戊醇 --> 1,2,3,5-四氢-8-硫杂-5,7-二氮-环戊基[A]茚-4-酮 --> 7-羟基-2-氧代-2H-苯并吡喃-3-甲酸甲酯 --> 3-(三氟甲氧基)肉桂酸 --> 对氟肉桂酸 --> 3,5-二甲氧基肉桂酸 --> 3,4-(亚甲二氧)肉桂酸 --> 2-氨基环戊并[B!噻吩-3-甲酸乙酯 --> 丁香醛 --> 1-(2-氨乙基)哌啶 --> 2,3-萘基二缩醛 --> 2-氨基-6-甲基-4,5,6,7-四氢-1-苯并噻吩-3-甲酰胺 --> 3-(3-甲基-2-噻吩)丙烯酸 --> 2-氨基-4,5,6,7-四氢苯并噻酚-3-羧酸乙酯 --> 2-氨基-5,6-二氢-4H-环戊烯并噻吩-3-甲酸甲酯 --> 甲苯哌丙酮 --> 磷酸苯丙哌林
  • FEMA:2908
  • 使用限量:FEMA(mg/kg)：饮料3.0；糖果5.0；焙烤食品0.05～5.0；调味料0.05；汤(料)0.05。 适度为限(FDA，§172．515，2000)。
  • 可燃性危险特性:遇明火、高温、氧化剂易燃; 受热分解有毒氧化氮气体
  • 用途五:哌啶又称六氢吡啶，是杀菌剂苯锈啶和植物生长调节剂甲哌鎓的中间体。
  • 急性毒性:口服- 大鼠 LD50: 400 毫克/ 公斤; 口服- 小鼠 LD50: 30 毫克/ 公斤
  • 所属类别三:食品添加剂: 食用香料（增香剂）: 天然等同香料和人造香
  • 用途四:六氢吡啶又称哌啶，是植物生长调节剂甲哌鎓的中间体。
  • {Chemicalb
  • 蒸气密度:3 (vs air)
  • 所属类别一:农药中间体: 杀菌剂中间体: 其他
  • 灭火剂:干粉、干砂、二氧化碳、泡沫
  • Alfa Aesar:哌啶,99% Piperidine, 99%(110-89-4)
  • 图谱信息:六氢吡啶(110-89-4)核磁图( 13 CNMR) 六氢吡啶(110-89-4)质谱(MS) 六氢吡啶(110-89-4)核磁图( 1 HNMR) 六氢吡啶(110-89-4)红外图谱(IR1)
  • 蒸气压:23 mm Hg ( 20 °C)
  • Sigma Aldrich:110-89-4(sigmaaldrich)
  • F:3-34
  • 类别:易燃液体
  • 六氢吡啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 AW29080701 哌啶;一氮六环; 胡椒环; 环五甲亚胺; 哌哔定; 六氢吡啶; 氮杂环己烷 sample 589元 2011/08/23 80104219 哌啶（易制毒-2） kg 155.5元 2011/08/23 80104216 哌啶（易制毒-2） 100ml 27元
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量（g/kg） 最大允许残留量（g/kg） 哌啶 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
  • 用途六:哌啶用于制造局部麻醉药、止痛药、杀菌剂、润湿剂、环氧树脂固化剂、橡胶硫化促进剂等。
  • 上游原料:钠 --> 氢 --> 哌啶盐酸盐
  • 参考质量标准:FCC，1996 含量 ≥98.0% 折射率 l.450～1.454 相对密度 0.858～0.862
  • 用途二:在有机合成中用作缩合剂及溶剂

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Application Areas 应用领域分类
  2. Flavors and Fragrances 香精香料
  3. Alphabetical Listings - Flavors and Fragrances
  4. O-P - Alphabetical Listings
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Humulus lupulus (Hops) - Phytochemicals by Plant (Food/Spice/Herb)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Homopiperidines 同哌啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperazines 哌嗪
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperidines 哌啶
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Analytical Reagents for General Use - Analytical Reagents
  4. Puriss p.a. - Analytical Reagents for General Use
  5. O-P, Puriss p.a. - Puriss p.a.
  1. Analytical & Chromatography 分析化学与色谱
  2. Solvents 溶剂
  3. Solvent Packaging Options - Solvents
  4. Solvent Bottles - Solvent Packaging Options
  5. Amber Glass Bottles - Solvent Bottles
  6. Biotech - Amber Glass Bottles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperidines 哌啶
  5. C5 to C7 - Piperidines
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Chelation/Complexation Compounds
  4. Calixarenes 杯芳烃
  1. Analytical & Chromatography 分析化学与色谱
  2. Adsorbents, Filter Aids and Drying Agents
  3. Other Drying Agents