4-Nitrophenyl4-(Bis(Benzo[D][1,3]Dioxol-5-Yl)(Hydroxy)Methyl)Piperidine-1-Carboxylate 4-硝基苯基4-(双(苯并[D][1,3]二恶英-5-Yl)(羟基)甲基)哌啶-1-羧酸盐

CAS 1101854-58-3 MFCD201854583

化学结构图

1101854-58-3
SMILES: [O-][N+](=O)C1C=CC(=CC=1)OC(=O)N1CCC(CC1)C(O)(C1=CC2OCOC=2C=C1)C1C=C2OCOC2=CC=1

化学属性

Mol. Weight520.49 (anhydrous basis)
Mol. FormulaC27H24N2O9· xH2O

别名和识别编码

Chemical Name4-Nitrophenyl4-(Bis(Benzo[D][1,3]Dioxol-5-Yl)(Hydroxy)Methyl)Piperidine-1-Carboxylate
CAS Number1101854-58-3 (anhydrous)
Synonym JZL184 hydrate
MDL NumberMFCD12912421
PubChem Substance ID329815406
Chemical Name Translation4-硝基苯基4-(双(苯并[D][1,3]二恶英-5-Yl)(羟基)甲基)哌啶-1-羧酸盐
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Cannabinoids, J, Metabolites, Inhibitors and Activators of Fatty Acid Metabolism, Monoacylglycerol Lipase Inhibitors, Neurobiology, Neuroscience, Pharmacologicals, 生物活性小分子, 癌症代谢, 癌症发生过程中的脂肪酸代谢, 癌症研

相关文献及参考

  • [2]. Pan B, et al. Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. J Pharmacol Exp Ther. 2009 Nov;331(2):591-7.
  • [1]. Long JZ, et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol. 2009 Jan;5(1):37-44.
  • [1]. Long JZ, et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol. 2009 Jan;5(1):37-44.
  • [2]. Pan B, et al. Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. J Pharmacol Exp Ther. 2009 Nov;331(2):591-7.

安全信息

Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
GHS Symbol
Precautionary statements
  • P301+P310
Signal word Danger
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. MAGL  (单酰甘油酯酶)

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