Chlorpheniramine Maleate 马来酸氯苯那敏

CAS 113-92-8 MFCD00069225

化学结构图

113-92-8
SMILES: CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O

化学属性

Mol. FormulaC16H19ClN2.C4H4O4
Mol. Weight391
Melting Point130-135
TSCAYes
SolubilityDMSO 78 mg/mL Water 78 mg/mL Ethanol 78 mg/mL

别名和识别编码

Chemical NameChlorpheniramine Maleate
CAS Number113-92-8
Synonym (±)-Chlorpheniramine maleate salt (±)-Chlorpheniramine maleate salt 1-(p-Chlorphenyl)-1-(2-pyridyl)-3-dimethylamino 1-(p-chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropanmaleat 1-p-Chlorophenyl-1 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benz 2-[p-Chloro-?-(2-dimethyl-aminoethyl)benzyl]p Allergisan Alunex C-Meton CHLORPHENAMINE MALEATE Chlor-tripolon Chloroprophenpyridamine maleate Chlorphenamine hydrogen maleate; 1-p-Chlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleat Ibioton LABOTEST-BB LT00134667 Polaronil Pyridamal-100 al c-meton chlormene dl-2-(p-chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridinemaleate {} {Chemicalbook} {} {} {} {} {Chemica 扑尔敏 氯苯
MDL NumberMFCD00069225
PubChem Substance ID5281068
EC Number204-037-5
Reaxys-RN4117059
Merck Number2180
Chemical Name Translation马来酸氯苯那敏
Wiswesser Line NotationT6NJ BYR DG&2N1&1 &OV1U1VO
Beilstein Registry Number4117059
LabNetwork Molecule IDLN00831818
InChIInChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
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分类

  • {SA} Antagonists, Cell Biology, Cell Signaling and Neuroscience, Histaminergics, Neuroscience, Neurotransmission, Neurotransmitters
  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bayer, Bioactive Small Molecule Alphabetical Index, C-CH, Diversification Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Histaminergics, Histaminergics - Antagonists, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学,

产品应用

  • Antihistaminic.

相关文献及参考

  • [2]. Kelly, J.X., et al., Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother, 2007. 51(11): p. 4133-40.
  • [3]. Iemura, R., et al., Synthesis of 2-(4-substituted-1-piperazinyl)benzimidazoles as H1-antihistaminic agents. J Med Chem, 1986. 29(7): p. 1178-83.
  • [4]. Takano, N., I. Arai, and M. Kurachi, Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol, 2003. 471(3): p. 223-8.
  • Akaishi, Y., et al., Involvement of tyrosine phosphorylation in the positive inotropic effect produced by H(1)-receptors with histamine in guinea-pig left atrium. Br. J. Pharmacol. 130 , 907-915, (2000)
  • Merck 14 ,2180
  • Roth, F.E., et al.: J. Pharmacol. Exp. Ther., 124, 347 (1958),
  • Smith, R.B., et al.: Toxicol. Appl. Pharmacol., 28, 240 (1974),
  • Sugimoto, Y.,

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P310
  • P301+P312+P330
  • P308+P311
  • P308+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger Warning {} {} {} {} {} {} {TCI}
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H301 Toxic if swallowed 吞食有毒
Hazard Codes 6.1 T Xn
RTECSUS6503000
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R25 Toxic if swallowed 吞咽有毒
UN Number 2811 UN 2811 6.1/PG 3
Storage condition 储存温度-20°C
Packing GroupIII 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 68 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 113,313,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,537,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 76700 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 113,72,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 101 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 113,72,1955

{haz

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 125 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-317,1986

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-317,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 420 mg/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,188,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4200 mg/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - abortion
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,188,1968

其他信息

  • MOL 文件:113-92-8.mol
  • 生产方法:由氯屈米通与顺丁烯二酸成盐而得。
  • RTECS号:US6504000
  • 用途:用作抗过敏药
  • 马来酸氯苯那敏价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0873 马来酸氯苯那敏 Chlorpheniramine Maleate 25G 539元 2010/05/25 B25238 马来酸氯苯那敏,99% Chlorpheniramine maleate, 99% 5g 344元 2010/05/25 B25238 马来酸氯苯那敏,99% Chlorpheniramine maleate, 99% 25g 792元
  • EPA化学物质信息:2-Pyridinepropanamine, .gamma.-(4-chlorophenyl)-N, N-dimethyl-, (2Z)-2-butenedioate (1:1)(113-92-8)
  • (±)-Chlorpheniramine maleate salt
  • PackingGroup:III
  • HazardClass:6.1(b)
  • 图谱信息:马来酸氯苯那敏(113-92-8)质谱(MS) 马来酸氯苯那敏(113-92-8)核磁图( 1 HNMR) 马来酸氯苯那敏(113-92-8)红外图谱(IR1) 马来酸氯苯那敏(113-92-8)核磁图( 13 CNMR) 马来酸氯苯那敏(113-92-8)红外图谱(IR2)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Histaminergics - Neurotransmitters
  8. Antagonists - Histaminergics
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

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