MK-571 Sodium Salt Hydrate MK-571钠盐
CAS 115103-85-0 MFCD11114392
化学结构图
SMILES: [Na+].CN(C)C(=O)CCSC(SCCC([O-])=O)C1C=C(C=CC=1)/C=C/C1C=CC2C=CC(Cl)=CC=2N=1
化学属性
| Mol. Formula | C26H26ClN2NaO3S2· xH2O |
|---|---|
| Mol. Weight | 537.07 (anhydrous basis) |
别名和识别编码
| Chemical Name | MK-571 Sodium Salt Hydrate |
|---|---|
| Synonym | 5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid sodium salt hydrate 5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid sodium salt hydrate L-660711 L-660711 MK-571 sodium salt hydrate |
| MDL Number | MFCD11114392 |
| CAS Number | 115103-85-0 (anhydrous) |
| PubChem Substance ID | 329817910 |
| Chemical Name Translation | MK-571钠盐 |
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分类
- Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Cell Biology, Cell Signaling and Neuroscience, Leukotrienes, Lipids in Cell Signaling, Merck
- {SNA} Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Cell Biology, Cell Signaling and Neuroscience, Leukotrienes, Lipids in Cell Signaling, M
- {SNA} Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, Leukotrienes, Lipids in Cell Signaling, M, Merck & Co., Inc., Kenilworth,NJ, 生物活性小分子, 细胞信号转导和神经科学,
- {SNA} A
相关文献及参考
- [2]. Hara Y, et al. Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice. J Clin Invest. 2011 Jul;121(7):2888-97.
- Li, C., et al., Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia. Cell 131 , 940-951, (2007) 摘要
- Madgula, V.L., et al., Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport. J. Pharm. Pharmacol. 60 , 363-370, (2008) 摘要
- Wong, W.S., et al., Cysteinyl leukotriene receptor antagonist MK-571 alters bronchoalveolar lavage fluid proteome in a mouse asthma model. Eur. J. Pharmacol. 575 , 134-141, (2007) 摘要
- [1]. Jones TR, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective
- [1]. Jones TR, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D 4 receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28.
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
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