CAS 1168091-68-6 MFCD268091686-5-((2-Fluoro-4-Iodophenyl)Amino)-N-(2-Hydroxyethoxy)Imidazo[1,5-A]Pyridine-6-Carboxamide 5-((2-氟-4-碘苯基)氨基)-N-(2-羟基乙氧基)咪唑并[1,5-a]吡啶-6-甲酰胺 -LabNovo

SMILES: O=C(NOCCO)c1ccc2cncn2c1Nc1ccc(I)cc1F

Chemical Name	5-((2-Fluoro-4-Iodophenyl)Amino)-N-(2-Hydroxyethoxy)Imidazo[1,5-A]Pyridine-6-Carboxamide
Formula	C16H14FIN4O3
Synonym	GDC0623; GDC-0632; GDC 0632; G868; G 868; G-868.
IUPAC Name	5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
InChIKey	RFWVETIZUQEJEF-UHFFFAOYSA-N
InChI	InChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)
Canonical SMILES	O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=C1)=CN=C3)NOCCO
Chemical Name Translation	5-((2-氟-4-碘苯基)氨基)-N-(2-羟基乙氧基)咪唑并[1,5-a]吡啶-6-甲酰胺

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GDC-0623, also known as G-868, is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

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