AKN-028

CAS 1175017-90-9 MFCD275017909

化学结构图

1175017-90-9
SMILES: Nc1ncc(-c2ccncc2)nc1Nc1ccc2[nH]ccc2c1

化学属性

Mol. Weight302.33
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameAKN-028
FormulaC17H14N6
Synonym AKN-028; AKN 028; AKN028
IUPAC NameN2-(1H-indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine
InChIKeyJLRIJKVMMZEKDF-UHFFFAOYSA-N
InChIInChI=1S/C17H14N6/c18-16-17(22-13-1-2-14-12(9-13)5-8-20-14)23-15(10-21-16)11-3-6-19-7-4-11/h1-10,20H,(H2,18,21)(H,22,23)
Canonical SMILESNC1=NC=C(C2=CC=NC=C2)N=C1NC3=CC4=C(NC=C4)C=C3
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产品应用

  • AKN-028, the FLT3/KIT kinase inhibitor, is an orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3; STK1) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity. FLT3/KIT kinase inhibitor AKN-028 binds to and inhibits both the wild-type and mutated forms of FLT3 and SCFR. This may result in an inhibition of tumor cell proliferation in cancer cell types that overexpress these receptor tyrosine kinases. Check for active clinical trials or closed clinical trials using this agent.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. FLT3
  1. Medical Research Areas
  2. PI3K/AKT/mTOR
  3. Caspase

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