2-(5,6-Dimethyl-9-Oxo-9H-Xanthen-4-Yl)Acetic Acid 5,6-二甲基-9-氧-9-氢-氧杂蒽-4-乙酸

CAS 117570-53-3 MFCD00870555

化学结构图

117570-53-3
SMILES: Cc1ccc2c(=O)c3cccc(CC(=O)O)c3oc2c1C

化学属性

Mol. FormulaC17H14O4
Mol. Weight282
Appearance Light brown to brown solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name2-(5,6-Dimethyl-9-Oxo-9H-Xanthen-4-Yl)Acetic Acid
Synonym 5,6-Dimethylxanthenone-4-acetic Acid ASA404 Vadimezan ASA404; ASA 404; ASA404; AS1404; AS 1404; AS1404; DMXAA; Vadimezan DMXAA
MDL NumberMFCD00870555
PubChem Substance ID24724464
Chemical Name Translation5,6-二甲基-9-氧-9-氢-氧杂蒽-4-乙酸
Reaxys-RN4262852
FormulaC17H14O4
IUPAC Name(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)-acetic acid
InChIKeyXGOYIMQSIKSOBS-UHFFFAOYSA-N
InChIInChI=1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)
Canonical SMILESO=C(O)CC1=CC=CC(C2=O)=C1OC3=C2C=CC(C)=C3C
CAS Number117570-53-3
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分类

  • {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY
  • {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, DIG-DY, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • Vadimezan, also known as DMXAA and ASA404, is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages.

安全信息

GHS Symbol
Precautionary statements
  • P301+P312+P330
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
WGK Germany3
Signal word Warning
RTECSZD5536200
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Hazard Codes Xn,N
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R50/53
Storage condition 0-10°C Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. DIG-DY - Bioactive Small Molecules
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indazoles 吲唑
  1. Medical Research Areas
  2. Angiogenesis
  3. VDA
  1. Medical Research Areas
  2. Apoptosis
  3. TNF-alpha

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