N,N-Dimethylaniline N,N-二甲基苯胺

CAS 121-69-7 MFCD00008304

化学结构图

121-69-7
SMILES: CN(C)c1ccccc1

化学属性

Mol. FormulaC8H11N
Mol. Weight121
Density0.95
Refractive index1.5560 to 1.5600
Boiling Point193-194
Melting Point1.5-2.5
Flash Point73°C(lit.)
TSCAYes
Solubility1 G/L (20 ºC)
Stability对光敏感
pH:A

别名和识别编码

Chemical NameN,N-Dimethylaniline
Synonym (Dimethylamino)benzene (Dimethylamino)benzol ACETIC ACID DIMETHYLAMIDE Aniline, N,N-dimethyl- DIMETHYLAMINOBENZENE Dimethylanilin Dimethylphenylamine N,N-(Dimethylamino)benzene N,N-DIMETHYLACETAMIDE N,N-Dimethylaminobenzene N,N-Dimethylaminobenzol N,N-Dimethylaniline N,N-Dimethylbenzenamine N,N-dimethyl-aniline N,N-二甲基苯胺 N,N-二甲苯胺,二甲基苯胺 N-二甲基苯胺 NCI-C56428 Versneller NL 63/10 u-5954 二甲氨基苯
CAS Number121-69-7
EC Number204-493-5
Beilstein Registry Number 507140
MDL NumberMFCD00008304
PubChem Substance ID949
Merck Number3234
Reaxys-RN507140
Chemical Name TranslationN,N-二甲基苯胺
Wiswesser Line Notation1N1&R
LabNetwork Molecule IDLN00198806
InChIInChI=1S/C8H11N/c1-9(2)8-6-4-3-5-7-8/h3-7H,1-2H3
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分类

  • {SNA} Amines, Building Blocks, C8, Chemical Synthesis, Essential Chemicals, Inorganic Salts, Solutions and Reagents, Nitrogen Compounds, Organic Building Blocks, Reagent Plus, Research Essentials
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {SNA} Amines, Building Blocks, C

产品应用

  • 检定甲醇、甲基呋喃甲醛、过氧化氢、硝酸盐、乙醇、甲醛和叔胺，比色测定亚硝酸盐等，溶剂，制造香荚兰素、甲基紫、米蚩酮和其他染料。亦用于对称和不对称光导体新工艺。

相关文献及参考

  • For an example of ortho-lithiation, followed by Pd-catalyzed coupling wth a vinyl bromide, see: Org. Synth. Coll., 7, 172 (1990).
  • Short: II/25D
  • Base for acylation reactions; see, e.g.: Org. Synth. Coll., 3, 142 (1955), 4, 263 (1963); 5, 171 (1973).
  • Short: II/19b
  • The AlCl3 complex with has been used to cleave benzyl and allyl ethers: Tetrahedron Lett., 32, 1321 (1991).

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Risk Statements
  • R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R36 Irritating to eyes 刺激眼睛
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R51/53
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P312+P330
  • P302+P350
  • P304+P340
  • P305+P351+P338
  • P308+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P332+P313
  • P337+P313
  • P370+P378
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301+H311+H331
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSBX4725000
Packing GroupII
UN Number 2253 UN 2253 6.1/PG 2
Hazard Codes 6.1 T,N
Storage condition 密封避光保存。 0-6°C
Hazard Class6.1
Warnings 危化品目录(2015) 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15450 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-360,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15450 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-360,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1410 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   23,95,1962

TYPE OF TEST            : LDLo - Lowest published let

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/m3/4H
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 37(4),35,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1770 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   23,95,1962

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Gastrointestinal - other changes
REFERENCE :
   NCPBBY National Clearinghouse for Poison Control Centers, Bulletin.  (U.S.
   Department of Health, Education, and Welfare, Washington, DC)
   Volume(issue)/page/year: Jan/Feb,1969

TYPE O

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 900 umol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   21,349,1993

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 485 mg/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   21,349,1993

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 30 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   13,60,1989

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 83 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   13,60,1989

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 485 mg/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   21,349,1993

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 20 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Vo

Restrict 危险品

其他信息

  • {
  • 毒性分级:中毒
  • Alfa Aesar:N,N-二甲基苯胺,99% N,
  • 下游产品:2,6-二三氟甲基-4-氯嘧啶 --> 亚甲兰 --> 碱性蓝 26 --> 2-三氟甲基-4-氯嘧啶 --> 6-氰嘌呤 --> 2,4-二甲氧基嘧啶-6-甲酸 --> 6-苄胺基嘌呤 --> 3-[(甲氧羰基)氨基]苯基-N-(3-甲基苯基)氨基甲酸酯 --> 米非司酮 --> 甲基红 --> 2-氨基-4-乙基吡啶 --> 酸性紫 17 --> 敌克松 --> 2,4-二硝基苯甲醛 --> 6-碘嘌呤 --> N,N,N',N'-四甲基联苯胺 --> 4,6-二氯-5-溴嘧啶 --> 6-二甲基氨基嘌呤 --> 4,4'-(对二甲氨基)二苯基甲烷 --> 碱性品绿 --> 溶剂紫 8 --> 4-溴-N,N-二甲基苯胺 --> 碱性兰53 --> 助拨剂 O,二甲基苄基苯基氯化铵 --> 金胺 --> 2,4-二氯-5-氟嘧啶 --> 7-甲基鸟嘌呤 --> 4,4^<'^>-双(二甲基氨基)二苯甲酮 --> 碱性红22 --> 健那绿 B --> 碱性染料 --> N,N-二甲基-3-硝基苯胺
  • 刺激数据:皮肤- 兔子 10 毫克/24小时 轻度; 眼-兔子 LD50: 20 毫克/24小时 中度
  • N,N-二甲基苯胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80051218 N，N-二甲基苯胺;二甲氨基苯 500ml 25元 2011/08/23 80051228 N，N-二甲基苯胺;二甲氨基苯 500ml 24元 2011/04/16 D3866 N,N-二甲基苯胺[用于生化研究] N,
  • 防护措施:高毒。吸入其蒸气或经皮肤吸收引起中毒。其毒性和苯胺大致相同。具有血液毒、神经毒和致癌性。空气中最高容许浓度5×10 -6。应避免与皮肤接触。操作现场应有良好通风，设备应密闭。操作人员要穿戴防护用具。
  • 爆炸物危险特性:与空气混合可爆
  • 图谱信息:N,N-二甲基苯胺(121-69-7)核磁图( 13 CNMR) N,N-二甲基苯胺(121-69-7)红外图谱(IR1) N,N-二甲基苯胺(121-69-7)质谱(MS) N,N-二甲基苯胺(121-69-7)核磁图( 1 HNMR)
  • MOL 文件:121-69-7.mol
  • 常规方法:采用铁桶密封包装，每桶180kg。贮存于阴凉通风处。按易燃有毒物品规定贮运。
  • 蒸气密度:3 (vs air)
  • 类别:有毒物品
  • 用途五:检定甲醇、甲基呋喃甲醛、过氧化氢、硝酸盐、乙醇、甲醛和叔胺，比色测定亚硝酸盐等，溶剂，制造香荚兰素、甲基紫、米蚩酮和其他染料。亦用于对称和不对称光导体新工艺。
  • 用途四:该品为重要的染料中间体。可用于制备碱性嫩黄、碱性紫5BN、碱性品绿、碱性湖蓝BB、碱性艳蓝R、阳离子红2BL、艳红5GN、紫3BL、艳蓝等。在医药工业中，该品可用于制造头孢菌素V、磺胺-b-甲氧嘧啶、磺胺
  • MSDS 信息:N,N-二甲基苯胺(121-69-7).msds
  • Acros Organics:N,N-二甲基苯胺 N,N-Dimethylaniline, 99%(121-69-7)
  • N,N-二甲基苯胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80051218 N，N-二甲基苯胺;二甲氨基苯 500ml 25元 2011/08/23 80051228 N，N-二甲基苯胺;二甲氨基苯 500ml 24元 2011/04/16 D3866 N,N-二甲基苯胺[用于生化研究] N,N-Dimet
  • 蒸气压:2 mm Hg ( 25 °C)
  • 上游原料:氨基苯 --> 磷酸三甲酯
  • 方法一:由苯胺与甲醇在硫酸存在下，经高温高压反应而得。原料消耗定额：苯胺790kg/
  • 外观性质:黄色油状液体。
  • 用途四:该品为重要的染料中间体。可用于制备碱性嫩黄、碱性紫5BN、碱性品

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Analytical Reagents for General Use - Analytical Reagents
  4. Puriss p.a. ACS - Analytical Reagents for General Use
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. C12 - Amines
  1. C8 - Amines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amines 胺
  6. C7
  1. Analytical & Chromatography 分析化学与色谱
  2. Adsorbents, Filter Aids and Drying Agents
  3. Other Drying Agents