1-[1-(CYCLOOCTYLMETHYL)-1,2,3,6-TETRAHYDRO-5-(HYDROXYMETHYL)-4-PYRIDINYL]-3-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE HYDROCHLORIDE

CAS 1216621-00-9 MFCD09971083

化学结构图

1216621-00-9
SMILES:

化学属性

Mol. FormulaC24H35N3O2·HCl
Mol. Weight434.01

别名和识别编码

Chemical NameTrap-101 hydrochloride
Synonym 1-[1-(cyclooctylmethyl)-1,2,3,6-tetrahydro-5-(hydroxymethyl)-4-pyridinyl]-3-ethyl-1,3-dihydro-2Hbenzimidazol-2-one hydrochloride
MDL NumberMFCD09971083
CAS Number1216621-00-9
PubChem Substance ID329826831
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Neuropeptides, Opioid Peptides, Other Opioid Peptides, Peptides and Proteins, Peptides for Cell Biology, T, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Cell Biology, Cell Signaling and Neuroscience, Neuropeptides,

相关文献及参考

  • Camarda V, Fischetti C, Anzellotti N, Molinari P, Ambrosio C, Kostenis E, Regoli D, Trapella C., Pharmacological profile of NOP receptors coupled with calcium signaling via the chimeric protein G alpha qi5. Naunyn Schmiedebergs Arch. Pharmacol. 6th ed., 379 , 599-607, (2009)
  • Mahmoud S, Margas W, Trapella C, Calo' G, Ruiz-Velasco V., Modulation of Silent and Constitutively Active Nociceptin/Orphanin FQ Receptors by Potent Receptor Antagonists and Na+ Ions in Rat Sympathetic Neurons. Mol. Pharmacol. Penn State , (2010)
  • Marti M, Trapella C, Morari M., The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA. J. Neurochem. 6th ed., 107 , 1683-1696, (2008)
  • [1]. Matteo Marti, et al. The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positiv

安全信息

GHS Symbol
Precautionary statements
  • P301+P310
Signal word Danger
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
WGK Germany3
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒

系列性分类

  1. Neuropeptides - Peptides for Cell Biology
  2. Opioid Peptides - Neuropeptides
  3. Other Opioid Peptides - Opioid Peptides
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Opioid Receptor  (阿片受体)

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