2-((5-Chloro-2-((1-Isopropyl-3-Methyl-1H-Pyrazol-5-Yl)Amino)Pyridin-4-Yl)Amino)-N-Methoxybenzamide 2-((5-氯-2-((1-异丙基-3-甲基-1H-吡唑-5-基)氨基)吡啶-4-基)氨基)-N-甲氧基苯甲酰胺
CAS 1224887-10-8 MFCD324887108
化学结构图
SMILES: CONC(=O)c1ccccc1Nc1cc(Nc2cc(C)nn2C(C)C)ncc1Cl
化学属性
| Mol. Weight | 414.894 |
|---|---|
| Appearance | White to off-white solid powder. |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 2-((5-Chloro-2-((1-Isopropyl-3-Methyl-1H-Pyrazol-5-Yl)Amino)Pyridin-4-Yl)Amino)-N-Methoxybenzamide |
|---|---|
| Formula | C20H23ClN6O2 |
| Synonym | GSK2256098; GSK 2256098; GSK-2256098; GTPL7939; GTPL-7939; GTP L7939. |
| IUPAC Name | 2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide |
| InChIKey | BVAHPPKGOOJSPU-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24) |
| Canonical SMILES | CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C |
| Chemical Name Translation | 2-((5-氯-2-((1-异丙基-3-甲基-1H-吡唑-5-基)氨基)吡啶-4-基)氨基)-N-甲氧基苯甲酰胺 |
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产品应用
- GSK2256098, also known as GTPL7939, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor GSK2256098 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thereby inhibiting tumor cell migration, proliferation and survival, and tumor angiogenesis. The tyrosine kinase FAK is normally activated by binding to integrins in the extracellular matrix (ECM) but may be upregulated and constitutively activated in various tumor cell types.
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