(R)-4-(2-(1H-indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine (R)-4-(2-(1H-吲哚-4-基)-6-(1-(甲基磺酰基)环丙基)嘧啶-4-基)-3-甲基吗啉
CAS 1233339-22-4 MFCD333339224
化学结构图
SMILES: C[C@@H]1COCCN1c1cc(C2(S(C)(=O)=O)CC2)nc(-c2cccc3[nH]ccc23)n1
化学属性
| Mol. Formula | C21H24N4O3S |
|---|---|
| Mol. Weight | 412.51 |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | (R)-4-(2-(1H-indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine |
|---|---|
| Chemical Name Translation | (R)-4-(2-(1H-吲哚-4-基)-6-(1-(甲基磺酰基)环丙基)嘧啶-4-基)-3-甲基吗啉 |
| Chemicalbook ID | CB32655393 |
| Formula | C21H24N4O3S |
| Synonym | AZ20; AZ-20; AZ 20. |
| IUPAC Name | (R)-4-(2-(1H-indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine |
| InChIKey | SCGCBAAYLFTIJU-CQSZACIVSA-N |
| InChI | InChI=1S/C21H24N4O3S/c1-14-13-28-11-10-25(14)19-12-18(21(7-8-21)29(2,26)27)23-20(24-19)16-4-3-5-17-15(16)6-9-22-17/h3-6,9,12,14,22H,7-8,10-11,13H2,1-2H3/t14-/m1/s1 |
| Canonical SMILES | C[C@H]1N(C2=NC(C3=CC=CC4=C3C=CN4)=NC(C5(S(=O)(C)=O)CC5)=C2)CCOC1 |
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产品应用
- AZ20 is an ATR protein kinase inhibitor, which inhibits ATR immunoprecipitated from HeLa nuclear extracts with an IC50 of 5 nM and ATR mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma tumor cells with an IC50 of 50 nM. AZ20 potently inhibits the growth of LoVo colorectal adenocarcinoma tumor cells in vitro and has high free exposure in mouse following moderate oral doses. AZ20 is a useful compound to explore ATR pharmacology in vivo.
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