ICI 216,140
CAS 124001-41-8 MFCD00153815
化学结构图
SMILES: CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC1=CNC2C=CC=CC1=2)NC(=O)[C@H](CC1=CNC=N1)NC(=O)C(C)C)C(C)C
化学属性
| Mol. Formula | C45H65N13O8 |
|---|---|
| Mol. Weight | 916.08 |
别名和识别编码
| Chemical Name | ICI 216,140 |
|---|---|
| Synonym | (CH3)2CHCO-His-Trp-Ala-Val-D-Ala-His-Leu-NHCH3 ICI 216,140 |
| MDL Number | MFCD00153815 |
| CAS Number | 124001-41-8 |
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分类
- Biochemicals and Reagents, Bombesin - Receptor Antagonists, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Other Peptides, Peptides and Proteins, Peptides for Cell Biology, Proteins and Derivatives
- {SNA} Biochemicals and Reagents, Bombesin - Receptor Antagonists, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Other Peptides, Peptides and Proteins, Peptides for Cell Biology, Proteins and Derivatives
相关文献及参考
- Camble, R., et al., N-Isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216140) a potent in vivo antagonist analog of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sci. 45 , 1521-1527, (1989) 摘要
- Yoshida-Yoneda, E., et al., Peripheral bombesin induces gastric vagal afferent activation in rats. Am. J. Physiol. 271 , R1584-R1593, (1996) 摘要
- Ryan, R.R., et al., Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur . J. Pharmacol. 306 , 307-314, (1996)
- Ren, G., et al., Melanin-targeted preclinical PET imaging of melanoma metastasis. J. Mol. Neurosci. 50 , 1692-9, (2009) 摘要
- Camble, R., et al., ICI 216140 and other potent in vivo antagonist analogs of bombesin/gastrin-releasing peptide. Proc. 11th Am. Peptide Symp. , (1989), 174
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