1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethan-1-one 1-(5-((2,4-二氟苯基)硫基)-4-硝基噻吩-2-基)乙酮

CAS 1247819-59-5 MFCD347819595

化学结构图

1247819-59-5
SMILES: CC(=O)c1cc([N+](=O)[O-])c(Sc2ccc(F)cc2F)s1

化学属性

Mol. Weight315.31
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation1-(5-((2,4-二氟苯基)硫基)-4-硝基噻吩-2-基)乙酮
Chemical Name1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethan-1-one
FormulaC12H7F2NO3S2
Synonym P22077; P-22077; P 22077.
IUPAC Name1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone
InChIKeyRMAMGGNACJHXHO-UHFFFAOYSA-N
InChIInChI=1S/C12H7F2NO3S2/c1-6(16)11-5-9(15(17)18)12(20-11)19-10-3-2-7(13)4-8(10)14/h2-5H,1H3
Canonical SMILESCC(C1=CC([N+]([O-])=O)=C(SC2=CC=C(F)C=C2F)S1)=O
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产品应用

  • P22077 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor. P22077 potently induces apoptosis in NB cells with an intact USP7-HDM2-p53 axis but not in NB cells with mutant p53 or without human homolog of MDM2 (HDM2) expression. P22077 also significantly augmented the cytotoxic effects of doxorubicin (Dox) and etoposide (VP-16) in NB cells with an intact USP7-HDM2-p53 axis. Moreover, P22077 was found to be able to sensitize chemoresistant LA-N-6 NB cells to chemotherapy. In an in vivo orthotopic NB mouse model, P22077 significantly inhibited the xenograft growth of three NB cell lines. USP7-specific inhibitors like P22077 may serve not only as a stand-alone therapy but also as an effective adjunct to current chemotherapeutic regimens for treating NB with an intact USP7-HDM2-p53 axis.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Apoptosis
  3. Mdm2

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