R-(-)-7-Chloro-8-Hydroxy-3-Methyl-1-Phenyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine, Hydrochloride (5R)-8-氯-3-甲基-5-苯基-2,3,4,5-四氢-1H-3-苯并氮杂卓-7-醇盐酸盐
CAS 125941-87-9 MFCD00069249
化学结构图
SMILES: Cl.CN1C[C@@H](C2=CC(O)=C(Cl)C=C2CC1)C1C=CC=CC=1
化学属性
| Mol. Formula | C17H18ClNO · HCl |
|---|---|
| Mol. Weight | 324.24 |
别名和识别编码
| Chemical Name | R-(-)-7-Chloro-8-Hydroxy-3-Methyl-1-Phenyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine, Hydrochloride |
|---|---|
| CAS Number | 125941-87-9 |
| Synonym | (5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol Hydrochloride (R)-Sch 23390 Hydrochloride R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride R(+)-SCH-23390 hydrochloride |
| MDL Number | MFCD00069249 |
| PubChem Substance ID | 24277910 |
| Chemical Name Translation | (5R)-8-氯-3-甲基-5-苯基-2,3,4,5-四氢-1H-3-苯并氮杂卓-7-醇盐酸盐 |
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分类
- Chiral Reagents
- Heterocycles
- Pharmaceuticals
- {SNA} Antagonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics, Neuroscience, Neurotransmission, Neurotransmitters, S
- {SNA} Antagonists, Bioactive Small Molecule Alphabetical Index, Dopaminergics, Neuroscience, Neurotransmission, Neurotransmitters, S, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Intermediates & Fine Chemicals
- Aromatics
产品应用
- A selective dopamine D1 receptor antagonist.
相关文献及参考
- [2]. Millan MJ, et al. The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors. Psychopharmacology (Berl). 2001 Jun;156(1):58-62.
- [3]. Kuzhikandathil EV, et al. Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupledinwardly rectifying potassium channels. Mol Pharmacol. 2002 Jul;62(1):119-26.
- [4]. Wang YH, et al. Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway. Acta Pharmacol Sin. 2020 Feb;41(2):173-180.
- [5]. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9.
- Hiroi, N., et al.: Brain Res., 552, 141 (1991),
- Kafka, S., et al.: Eur. J .Pharmacol., 295,
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