Tetrakis(Acetoxymethyl) 1,2-Bis(2-Aminophenoxy)Ethane-N,N,N,N-Tetraacetate 1,2-双(2-氨基苯氧基)乙烷-N,N,N,N-四乙酸四(乙酰氧基甲酯)

CAS 126150-97-8 MFCD00036696

化学结构图

126150-97-8
SMILES: CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1C=CC=CC=1OCCOC1C=CC=CC=1N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O

化学属性

Mol. FormulaC34H40N2O18
Mol. Weight764.69
Melting Point96.0 to 100.0 deg-C

别名和识别编码

Chemical NameTetrakis(Acetoxymethyl) 1,2-Bis(2-Aminophenoxy)Ethane-N,N,N,N-Tetraacetate
CAS Number126150-97-8
Synonym 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester) 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester) BAPTA-AM N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]glycine 1,1'-Bis[(acetyloxy)methyl] Ester
MDL NumberMFCD00036696
PubChem Substance ID172088961
Beilstein Registry Number 7458534
Reaxys-RN7458534
Chemical Name Translation1,2-双(2-氨基苯氧基)乙烷-N,N,N,N-四乙酸四(乙酰氧基甲酯)
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分类

  • {SNA} B, Bioactive Small Molecule Alphabetical Index, Calcium Chelators, Calcium Signaling Research Tools, Intracellular Calcium Signaling, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} B, Bioactive Small Molecules, Calcium Chelators, Calcium Signaling Research Tools, Cell Biology, Cell Signaling and Neuroscience, Intracellular Calcium Signaling
  • Amines
  • Fluorescent Labels & Indicators
  • Chelating Agents & Ligands
  • Aromatics

产品应用

  • BAPTA-AM is a lipophilic diester of BAPTA used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE.

相关文献及参考

  • Li, B., et al.: Brain Res., 1226, 199 (2008),
  • Chen, W., et al.: Mol. Endocrinol., 22, 1754 (2008),
  • Takahashi, T., et al. Circ. Res. 85 , 884, (1999) 摘要
  • Strayer, D.S., et al. Biochem. J. 344 , 39, (1999) 摘要
  • Brown, M.V., et al., PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway. Exp. Cell Res. 315 , 39-49, (2009) 摘要
  • Byfield, F.J., et al., Cathelicidin LL-37 Peptide Regulates Endothelial Cell Stiffness And Endothelial Barrier Permeability. Am. J. Physiol. Cell Physiol. 300 , C105-12, (2011) 摘要

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition <0°C

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. B - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Intracellular Calcium Signaling - Cell Signaling and Neuroscience
  5. Calcium Signaling Research Tools - Intracellular Calcium Signaling
  6. Calcium Chelators - Calcium Signaling Research Tools

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