((2S,3As,7As)-1-((R)-2-(((S)-2-(2-((2S,4R)-1-(D-Arginyl-L-Arginyl-L-Prolyl)-4-Hydroxypyrrolidine-2-Carboxamido)Acetamido)-3-(Thiophen-2-Yl)Propanoyl)-L-Seryl)-1,2,3,4-Tetrahydroisoquinoline-3-Carbonyl)Octahydro-1H-Indole-2-Carbonyl)-L-Arginine ((2S,3aS,7aS)-1-((R)-2-(((S)-2-(2-((2S,4R)-1-(D-精氨酰-L-精氨酰-L-脯氨酰)-4-羟基吡咯烷-2-甲酰胺基)乙酰胺基)-3-(噻吩-2-基)丙酰基)-L-丝氨酸基)-1,2,3,4-四氢异喹啉-3-羰基)八氢-1H-吲哚-2-羰基)-L-精氨酸
CAS 130308-48-4 MFCD00213940
化学结构图
SMILES: N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2C=CC=CC=2C[C@@H]1C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
化学属性
| Mol. Formula | C59H89N19O13S |
|---|---|
| Mol. Weight | 1304.52 |
别名和识别编码
| Chemical Name | ((2S,3As,7As)-1-((R)-2-(((S)-2-(2-((2S,4R)-1-(D-Arginyl-L-Arginyl-L-Prolyl)-4-Hydroxypyrrolidine-2-Carboxamido)Acetamido)-3-(Thiophen-2-Yl)Propanoyl)-L-Seryl)-1,2,3,4-Tetrahydroisoquinoline-3-Carbonyl)Octahydro-1H-Indole-2-Carbonyl)-L-Arginine |
|---|---|
| Synonym | HOE 140 |
| MDL Number | MFCD00213940 |
| Chemical Name Translation | ((2S,3aS,7aS)-1-((R)-2-(((S)-2-(2-((2S,4R)-1-(D-精氨酰-L-精氨酰-L-脯氨酰)-4-羟基吡咯烷-2-甲酰胺基)乙酰胺基)-3-(噻吩-2-基)丙酰基)-L-丝氨酸基)-1,2,3,4-四氢异喹啉-3-羰基)八氢-1H-吲哚-2-羰基)-L-精氨酸 |
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分类
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Bradykinins, Bradykinnins - Receptor Antagonists, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, H, Membrane Protein Biology Tools, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Proteins and Derivatives
相关文献及参考
- [2]. Y Arai, et al. Effect of Icatibant, a Bradykinin B2 Receptor Antagonist, on the Development of Experimental Ulcerative Colitis in Mice. Dig Dis Sci. 1999 Apr;44(4):845-51.
- [3]. Marie-Thérèse Bawolak, et al The Bradykinin B2 Receptor Antagonist Icatibant (Hoe 140) Blocks Aminopeptidase N at Micromolar Concentrations: Off-Target Alterations of Signaling Mediated by the Bradykinin B1 and Angiotensin Receptors. Eur J Pharmacol. 2006 Dec 3;551(1-3):108-11.
- [1]. Hock FJ, et al. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br J Pharmacol. 1991 Mar;102(3):769-73.
- [1]. Hock FJ, et al. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br J Pharmacol. 1991 Mar;102(3):769-73.
- [2]. Y Arai, et al. Effect of Icatibant, a Bradykinin B2 Receptor Antagonist, on the Development of Experimental Ulcerative Colitis in Mice. Dig Dis Sci. 1999 Apr;44(4):845-51.
- [3]. Marie-Thérèse Bawolak, et al
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