3-(Piperidin-2-Yl)Pyridine 3-(哌啶-2-基)吡啶

CAS 13078-04-1 MFCD00006370

化学结构图

13078-04-1
SMILES: C1CCCC(N1)C1C=NC=CC=1

化学属性

Mol. FormulaC10
Mol. Weight162
Refractive index1.5440
Boiling Point270 - 272
Density1.046
Flash Point93°(199°F)
TSCANo
Melting Point9

别名和识别编码

Chemical Name3-(Piperidin-2-Yl)Pyridine
CAS Number13078-04-1
Synonym (+/-)-Anabasine (R,S)-1,2,3,4,5,6-Hexahydro-[2,3']bipyridinyl (R,S)-3-(2-Piperidinyl)pyridine (RS)-Anabasine (±)-Anabasine (±)-anabasine 1,2,3,4,5,6-Hexahydro-[2,3']bipyridinyl 1,2,3,4,5,6-hexahydro-(2,3')bipyridinyl 1,2,3,4,5,6-hexahydro-2,3'-bipyridine 2-(3-Pyridyl)piperidine 2-(Pyridin-3-yl)piperidine 2-pyridin-3-ylpiperidine 3-(2-Piperidyl)pyridine 3-(2-哌啶基)吡啶 3-(Piperidin-2-yl)pyridine Anabasine, (±)- DL-Anabasine Neonicotine Piperidine, 2-(3-pyridyl)- Pyridine, 3-(2-piperidinyl)- Pyridine, 3-(2-piperidinyl)-, (±)- racemic anabasine 新烟碱 毒藜碱
PubChem Substance ID24857169
MDL NumberMFCD00006370
Merck Number14,619
Beilstein Registry Number82639
Alfabeta NamePIPERIDINYLPYRIDINE 32---
Chemical Name Translation3-(哌啶-2-基)吡啶
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分类

  • AN-AZ, Agonists, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Botanicals, Building Blocks, C10, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Cholinergics, Chromatography, Environmental Standards, Heterocyclic Building Blocks, Insecticides, Ion Channels, Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Neurotransmitters, Nicotinic Acetylcholine Receptor Modulators, Pesticides, Pesticides & Metabolites, Pyridines
  • {SNA} AN-AZ,
  • {SNA} AN-AZ,

产品应用

  • A nicotinic receptor agonist

相关文献及参考

  • Alkondon, M., et al.: J. Pharmacol. Exp. Ther., 271, 494
  • Lu, Y., et al., Desensitization of nicotinic agonist-induced [ 3 H]γ-aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists. J. Pharmacol. Exp. Ther. 291 , 1127, (1999) 摘要
  • Parker, M.J., et al., Neuronal nicotinic receptor β 2 and β 4 subunits confer large differences in agonist binding affinity. Mol. Pharmacol. 54 , 1132-1139, (1998) 摘要
  • Kem, W.R., et al., Anabaseine is a potent agonist on muscle and neuronal α-bungarotoxin-sensitive nicotinic receptors. J. Pharmacol. Exp. Ther. 283 , 979, (1997) 摘要
  • Gocze, P.M., et al., Influence of nicotine, cotinine, anabasine and cigarette smoke extract on human granulosa cell progesterone and estradiol synthesis. Gynecol. Endocrinol. 13 , 266, (1999) 摘要
  • {uni_hamburg} Short: III/35D3 Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts for Carbon-13, Part 3: Heterocycles Author: Gupta, R.R.; Jain, M.; Lechner, M.D.; Mikhova, B.M. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35D3 Year: 2007 Keyword: C-13; NMR; carbon-13; chemical shifts; coupling constants; heterocycles; nuclear magnetic resonance ISBN: 978-3-540-29731-4 ISBN: 3-540-29731-6 Internet Resource: DOI: 10.1007/978-3-540-47067-0 RefComment: VIII, 342 p., 1 illus., Hardcover RefComment: Written for Science and engineers in the fields of physics, chemistry and physical chemistry who inted to use NMR to study the structure and the binding of molecules Abstract: Nuclear Magnetic Resonance (NMR) is based on the fact that certain nuclei exhibit a magnetic moment, orient by a magnetic field, and absorb characteristic frequencies in the radiofrequency part of the spectrum. NMR is now a leading technique and a powerful tool for the investigation of the structure and interaction of molecules.

安全信息

GHS Symbol
WGK Germany3
Hazard Codes 6.1 T
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H300 Fatal if swallowed 吞食致命
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSBV4375000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P302+P350
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P405 Store locked up. 上锁保管。
  • P501a
Signal word Danger
UN Number 3140
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R27/28 Very toxic in contact with skin and if swallowed 皮肤接触及吞食都有剧毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R51/53
Safety Statements
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S27/28
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S57 Use appropriate containment to avoid environmental contamination 使用适当容器避免环境污染;
Packing GroupI
Warnings IRRITANT

系列性分类


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