TRAPOXIN A

CAS 133155-89-2 MFCD00900598

化学结构图

133155-89-2
SMILES: O=C(CCCCC[C@@H]1NC(=O)[C@H]2CCCCN2C(=O)[C@H](CC2C=CC=CC=2)NC(=O)[C@H](CC2C=CC=CC=2)NC1=O)[C@@H]1CO1

化学属性

Mol. FormulaC34H42N4O6
Mol. Weight602.72

别名和识别编码

Chemical NameTrapoxin A
Synonym Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl) Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl) RF 1023A RF 1023A
CAS Number133155-89-2
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules for Epigenetic Research, Cyclic Tetrapeptide and Natural Product Inhibitors, DNA-RNA Transcription Regulators, Gene Regulation and Expression, Histone Deacetylase Inhibitors, T, 分子生物学, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 表观遗传学
  • {SA} Bioactive Small Molecules for Epigenetic Research, Cell Biology, Cell Signaling and Neuroscience, Cyclic Tetrapeptide and Natural Product Inhibitors, DNA-RNA Transcription Regulators, Epigenetics, Gene Regulation and Expression, Histone Deacetylase Inhibitors, Molecular Biology

相关文献及参考

  • 1. Fang, J.Y., and Lu, Y.Y., Effects of histone acetylation and DNA methylation on p21 (WAF1) regulation. World J. Gastroenterol. 8 , 400-405, (2002) 摘要
  • 2. Yoshida, M., et al., Trichostatin A and Trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. Bioessays 17 , 423-430, (1995)
  • 3. Vigushin, D.M., and Coombes, R.C., Histone deacetylase inhibitors in cancer treatment. Anti-Cancer Drugs 13 , 1-13, (2002)

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P301+P310
Signal word Danger
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒

系列性分类

  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Epigenetics - Molecular Biology
  4. Bioactive Small Molecules for Epigenetic Research - Epigenetics
  5. Histone Deacetylase Inhibitors - Bioactive Small Molecules for Epigenetic Research
  6. Cyclic Tetrapeptide and Natural Product Inhibitors - Histone Deacetylase Inhibitors

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