ELND006

CAS 1333990-84-3 MFCD433990843

化学结构图

1333990-84-3
SMILES: O=S(=O)(c1ccc(C(F)(F)F)cc1)N1c2cc(F)c(F)cc2-c2[nH]ncc2[C@H]1C1CC1

化学属性

Mol. Weight455.4
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameELND006
FormulaC20H14F5N3O2S
Synonym ELND006; ELND-006; ELND 006.
IUPAC Name(R)-4-cyclopropyl-7,8-difluoro-5-((4-(trifluoromethyl)phenyl)sulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline
InChIKeyXODSHWXKSMPDRP-LJQANCHMSA-N
InChIInChI=1S/C20H14F5N3O2S/c21-15-7-13-17(8-16(15)22)28(19(10-1-2-10)14-9-26-27-18(13)14)31(29,30)12-5-3-11(4-6-12)20(23,24)25/h3-10,19H,1-2H2,(H,26,27)/t19-/m1/s1
Canonical SMILESO=S(N1[C@H](C2CC2)C3=C(NN=C3)C4=C1C=C(F)C(F)=C4)(C5=CC=C(C(F)(F)F)C=C5)=O
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产品应用

  • ELND006 is a novel gamma secretase inhibitor previously under investigation for the oral treatment of Alzheimer's disease. ELND006 shows poor solubility and has moderate to high permeability. The in vivo performance of the ELND006 nanosuspension was tested in fed and fasted beagle dogs and compared with a gelatin capsule containing reference API. The results show that nanosizing ELND006 profoundly improved the oral bioavailability and virtually eliminated variation resulting from food intake.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. L01-Proteases (36) ||[cs]: . Proteases
  3. LCZ696 沙库巴曲缬沙坦钠
  4. Gamma-secretase
  1. Medical Research Areas
  2. Protein Tyrosine Kinase
  3. Gamma-secretase

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