Lobeline hydrochloride 盐酸洛贝林

CAS 134-63-4 MFCD00082455

化学结构图

134-63-4
SMILES: CN1[C@H](C[C@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1.Cl

化学属性

Mol. FormulaC22 H27 N O2 . Cl H
Mol. Weight373.92
Melting Point183-185 °C (dec.)(lit.)
SolubilityH2O: 25 mg/mL
Appearance powder
Refractive index-57.5 ° (C=1, H2O)

别名和识别编码

Chemical NameLobeline hydrochloride
MDL NumberMFCD00082455
CAS Number134-63-4
Synonym (-)-LOBELINE HCL (-)-LOBELINE HYDROCHLORIDE (-)-id (-)-洛贝林 盐酸盐 2-(6-(2-hydroxy-2-phenethyl)-1-methyl-2-piperidyl)acetophenone hydrochloride 2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-acetophenonhydrochlor 2-(6-[2-HYDROXY-2-PHENYLETHYL]-1-METHYL-2-PIPERIDINYL)-1-PHENYLETHANONE HYDROCHLORIDE 2-(6-[2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl)-1-phenylethanone, L-Lobeline, Hydrochloride 2-[(2r,6s)-6-[(2s)-2-hydroxy-2-phenyl-ethyl]-1-methyl-2-piperidyl]-1-phenyl-ethanone hydrochloride 2-[1-甲基-6-(beta-羟基苯乙基)-2-哌啶基]苯乙酮盐酸盐 2-[6-(.beta.-hydroxyphenethyl)-1-methyl-2-piperidyl]-,hydrochloride,(-)-Acetophenone 2-[6-(2-HYDROXY-2-PHENETHYL)-1-METHYL-2-PIPERIDYL]ACETOPHENONE HCL 2-[6-(2-羟基-2-苯乙基)-1-甲基-2-呱啶基]-1-苯乙酮 盐酸盐 (-)-洛贝林 盐酸盐 A-LOBELINE HCL A-LOBELINE, HYDROCHLORID
PubChem Substance ID46202
EC Number205-150-2
Beilstein Registry Number3920196
Chemical Name Translation盐酸洛贝林
Merck Number5551
Wiswesser Line NotationT6NTJ A1 B1YQR& F1VR &GH
LabNetwork Molecule IDLN01871764
InChIInChI=1S/C22H27NO2.ClH/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18;/h2-7,9-12,19-21,24H,8,13-16H2,1H3;1H
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分类

  • {SNA} Agonists, Asymmetric Synthesis, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Chiral Building Blocks, Cholinergics, Heterocyclic Building Blocks, L, Neuroscience, Neurotr
  • Agonists, Asymmetric Synthesis, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Chiral Building Blocks, Cholinergics, Heterocyclic Building Blocks, L, Neuroscience, Neurotransmission, Neurotransmitters, Piperidines

相关文献及参考

  • Merck 14 ,5551
  • Beil. 21 ,V,12,627
  • Aldrich MSDS 1 , 1143:B / Corp MSDS 1 (1), 2162:B / FT-IR 1 (2), 47:B / FT-IR 2 (2), 2432:A / FT-NMR 1 (2), 868:A / IR-Spectra (2), 766:H / IR-Spectra (3), 876:C / NMR-Reference 2 (2), 49:A / RegBook 1 (2), 1655:A / Sax 6 , 1713 / Sigma FT-IR 1 (1), 595:C / Structure Index 1 , 261:A:1

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T
Hazard statements
  • H331 Toxic if inhaled 吸入中毒
  • H301 Toxic if swallowed 吞食有毒
  • H301+H331
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSOJ8490100
Precautionary statements
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
Signal word Danger
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
Packing GroupIII
Hazard Class6.1(b)
UN Number UN 1544 6.1/PG 3 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,913,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 87500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,913,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 39900 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,913,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 163,279,1931

Storage condition -20 -20°C -20℃

其他信息

  • TCI Shanghai:盐酸洛贝林 Lobeline Hydrochloride,>;98.0%(LC)(T)(134-63-4)
  • Sigma Aldrich:134-63-4(sigmaaldrich)
  • F:8
  • 盐酸洛贝林价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 61003180 盐酸-L-山梗碱 g 165元
  • color:white to off-white
  • MOL 文件:134-63-4.mol

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperidines 哌啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acid Salts - Carbonyl Compounds
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Cholinergics - Neurotransmitters
  8. Agonists - Cholinergics
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Heterocyclic Building Blocks - Chiral Building Blocks
  5. Piperidines - Heterocyclic Building Blocks
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Alkaloids

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