Atorvastatin Calcium 阿伐他汀钙

CAS 134523-03-8 MFCD03613598

化学结构图

134523-03-8
SMILES: CC(C)C1=C(C(=C(C2C=CC(F)=CC=2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O[Ca]OC(=O)C[C@H](O)C[C@H](O)CCN1C(=C(C(=C1C(C)C)C(=O)NC1C=CC=CC=1)C1C=CC=CC=1)C1C=CC(F)=CC=1)C1C=CC=CC=1)C(=O)NC1C=CC=CC=1

化学属性

Mol. FormulaC33H34FN2O5· 0.5 Ca · 1.5 H2O
Mol. Weight604.69

别名和识别编码

Chemical NameAtorvastatin Calcium
Synonym
PubChem Substance ID329823670
Chemical Name Translation阿伐他汀钙
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分类

  • {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Fluorination Ready Pharma-Developed Compounds, Lipids in Cell Signaling, Other, Pfizer Compounds, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

相关文献及参考

  • [2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.
  • [3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82.
  • [4]. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72.
  • [5]. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821.
  • [1]. Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;14

安全信息

WGK Germany3

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. HMG-CoA Reductase (HMGCR)  (HMG-CoA还原酶)

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