(1α,2β,4β,5α,7β)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-di-methyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide (1α,2β,4β,5α,7β)-7-[2-羟基-2,2-二(2-噻吩基)乙酰氧]-9,9-二甲基-3-氧杂-9-氮阳离子三环[3.3.1.0]壬烷溴化物

CAS 136310-93-5 MFCD00867027

化学结构图

136310-93-5
SMILES: [Br-].C[N+]1(C)[C@@H]2C[C@H](C[C@H]1[C@@H]1O[C@H]21)OC(=O)C(O)(C1=CC=CS1)C1=CC=CS1

化学属性

Mol. FormulaC19H22BrNO4S2
Mol. Weight472

别名和识别编码

Chemical Name(1α,2β,4β,5α,7β)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-di-methyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide
CAS Number136310-93-5
Synonym (1?,2?,4?,5?,7?)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide
Chemical Name Translation(1α,2β,4β,5α,7β)-7-[2-羟基-2,2-二(2-噻吩基)乙酰氧]-9,9-二甲基-3-氧杂-9-氮阳离子三环[3.3.1.0]壬烷溴化物
MDL NumberMFCD00867027
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分类

  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds,

产品应用

  • Muscarinic receptor antagonist. Bronchodilator.

相关文献及参考

  • [2]. ZuWallack AR, ZuWallack RL. Tiotropium bromide, a new, once-daily inhaled anticholinergic bronchodilator for chronic-obstructive pulmonary disease. Expert Opin Pharmacother. 2004 Aug;5(8):1827-35.
  • [3]. Lipson DA. Tiotropium bromide. Int J Chron Obstruct Pulmon Dis. 2006;1(2):107-14.
  • [4]. Mamary AJ, Criner GJ. Tiotropium bromide for chronic obstructive pulmonary disease. Expert Rev Respir Med. 2009 Jun;3(3):211-20.
  • [5]. Szmidt M. [The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD)]. Pneumonol Alergol Pol. 2012;80(3):255-62.
  • Donohue, J. F., et al.: Chest, 122, 47 (2002),
  • Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994),
  • Profita, M., et al.: Allergy, 60, 1361 (2005),
  • [1]. Barnes PJ. Tiotropium

系列性分类


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