(R,R)-Et-DUPHOS-Rh 1,2-双[(2R,5R)-2,5-二乙基膦烷基]苯(1,5-环辛二烯)三氟甲磺酸铑(I)

CAS 136705-77-6 MFCD00269860

化学结构图

136705-77-6
SMILES: C1=C\CC/C=C\CC/1.CC[C@@H]1CC[C@@H](CC)P1c1ccccc1P1[C@H](CC)CC[C@H]1CC.O=S(=O)([O-])C(F)(F)F.[Rh+]

化学属性

Mol. FormulaC31H48F3O3P2RhS
Mol. Weight722.62
Appearance orange xtl.
Stabilityair sensitive, store cold

别名和识别编码

Chemical Name(R,R)-Et-DUPHOS-Rh
Synonym 1,2-双[(2R,5R)-2,5-二乙基膦烷基]苯(1,5-环辛二烯)三氟甲磺酸铑(I) (R,R)-Et-DUPHOS-Rh
MDL NumberMFCD00269860
CAS Number136705-77-6
Chemical Name Translation1,2-双[(2R,5R)-2,5-二乙基膦烷基]苯(1,5-环辛二烯)三氟甲磺酸铑(I)
PubChem Substance ID5702639
LabNetwork Molecule IDLN01808818
InChIInChI=1S/C22H36P2.C8H12.CHF3O3S.Rh/c1-5-17-13-14-18(6-2)23(17)21-11-9-10-12-22(21)24-19(7-3)15-16-20(24)8-4;1-2-4-6-8-7-5-3-1;2-1(3,4)8(5,6)7;/h9-12,17-20H,5-8,13-16H2,1-4H3;1-2,7-8H,3-6H2;(H,5,6,7);/p-1/b;2-1-,8-7-;;/t17-,18-,19-,20-;;;/m1.../s1
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分类

  • {SNA} Asymmetric Synthesis, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, DuPhos/BPE, Privileged Ligands and Complexes
  • Asymmetric Synthesis, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, DuPhos/BPE, Privileged Ligands and Complexes

相关文献及参考

  • 1. Starodubtseva, E. V.; et al., Stereocontrolled approach to d-amino acids by asymmetric hydrogenation of 5-acetylaminopent-4-enoic acid derivatives Russ. Chem. Bull. 59 , 1463-1466, (2010)
  • 2. Oe, K.; et al., Short and stereoselective synthesis of manzacidins A and C, and their enantiomers Tetrahedron Lett. 49 , 7426-7429, (2008)
  • 3. Kita, Y.; et al., Synthetic Studies on (+)-Manzamine A: Stereoselective Synthesis of the Tetracyclic Core Framework Org. Lett. 10 , 3251-3253, (2008)
  • 4. Hu, Z.; Han, W., An efficient chiral synthesis of fluoro-containing amino acids: N-benzyloxycarbonyl-2-amino-4,4-difluorobutyric acid methyl ester and its analogs Tetrahedron Lett. 49 , 901-902, (2008)
  • 5. Wolfson, A.; et al., Beneficial effect of water as second solvent in ionic liquid biphasic catalytic hydrogenations Tetrahedron Lett. 46 , 2513-2516, (2005)
  • 6. Aguado, G. P.; et al., Stereoselective Rh-Catalyzed Hydrogenation of Cyclobutyl Chiral Enamides: Double Stereodifferentiation vs Catalyst-Controlled Diastereoselection J. Org. Chem. 69 , 7971-7978, (2004)
  • 7. Wang, W.; Li, H., An efficient synthesis of the intrinsic fluorescent peptide labels, (S)- and (R)-(6,7-dimethoxy-4-coumaryl)alanines via asymmetric hydrogenations Tetrahedron Lett. 45 , 8479-8481, (2004)

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类


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