O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N′,N′-tetramethyluronium tetrafluoroborate O-[(乙氧羰基)氰基亚甲基氨基]-N,N,N′,N′-四甲基脲四氟硼酸酯

CAS 136849-72-4 MFCD00192127

化学结构图

136849-72-4
SMILES: CCOC(=O)/C(/C#N)=N\OC(N(C)C)=[N+](C)C.F[B-](F)(F)F

化学属性

Mol. FormulaC10H17BF4N4O3
Mol. Weight328
Melting Point144-145
TSCANo

别名和识别编码

Chemical NameO-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N′,N′-tetramethyluronium tetrafluoroborate
Synonym N-[[[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy](dimethylamino)methylene]-N-methyl-methanaminium tetrafluoroborate
MDL NumberMFCD00192127
CAS Number136849-72-4
Reaxys-RN13171579
PubChem Substance ID160871063
Chemical Name TranslationO-[(乙氧羰基)氰基亚甲基氨基]-N,N,N′,N′-四甲基脲四氟硼酸酯
Beilstein Registry Number13171579
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分类

  • {SNA} Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Phosphonium/Uronium/Formamidinium, Synthetic Reagents

产品应用

  • 新型脲正离子型多肽缩合剂，适用于条件苛刻的反应，产物消旋率较低。

相关文献及参考

  • 3. Werner Seitz, et al Bioorg. Med. Chem. Lett. 18 , 527-531, (2008)
  • 5. Birte Basler J. Org. Chem. 70 , 9798-9808, (2005)
  • Low racemization peptide coupling agent: Proc. 21st Eur. Pept. Symp., 1990, E. Giralt, D. Andren Eds., ESCOM, Leiden (1991), p143; Tetrahedron Lett., 33, 6625 (1992). See Appendix 6.

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P301+P330+P331+P310
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
Hazard Codes Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Storage condition Moisture Sensitive 0-10 储存温度： 2-8°C 0-10°C
UN Number 1759
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Packing GroupIII
Hazard Class8

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Peptides - Biochemicals and Reagents
  4. Peptide Synthesis 多肽合成
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  4. Phosgene Derivatives - Coupling
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  4. Phosphonium/Uronium/Formamidinium - Coupling
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  4. Phosphonium/Uronium/Formamidinium - Coupling
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Peptide Coupling - Peptide Chemistry
  5. Phosphonium/Uronium/Formamidinium - Peptide Coupling
  1. Functional Group 官能团索引
  2. isourea

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