PF-03671148

CAS 1378524-25-4 MFCD478524254

化学结构图

1378524-25-4
SMILES: Cc1cccc(-n2nccc2-c2ccc3ncn(C)c(=O)c3c2)n1

化学属性

Mol. Weight317.34
Appearance Solid powder
SolubilitySoluble in DMSO

别名和识别编码

Chemical NamePF-03671148
FormulaC18H15N5O
Synonym PF03671148; PF03671148; PF 03671148.
IUPAC Name3-methyl-6-(1-(6-methylpyridin-2-yl)-1H-pyrazol-5-yl)quinazolin-4(3H)-one
InChIKeyOWIYYKSTVQMPLM-UHFFFAOYSA-N
InChIInChI=1S/C18H15N5O/c1-12-4-3-5-17(21-12)23-16(8-9-20-23)13-6-7-15-14(10-13)18(24)22(2)11-19-15/h3-11H,1-2H3
Canonical SMILESO=C1N(C)C=NC2=C1C=C(C3=CC=NN3C4=NC(C)=CC=C4)C=C2
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产品应用

  • PF-03671148 is a potent ALK inhibitor. PF-03671148 inhibits the expression of fibrotic genes and protein markers both in vitro in human fibroblasts and in vivo in a rat wound repair model. Wound healing is not inhibited by the topical application of the ALK5 inhibitor to the wound. PF-03671148 may have potential utility for the prevention of dermal scarring.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. L01-Proteases (36) ||[cs]: . Proteases
  3. LCZ696 沙库巴曲缬沙坦钠
  4. ALK

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