GNE-317 GNE-317游离态
CAS 1394076-92-6 MFCD494076926
化学结构图
SMILES: COC1(c2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)COC1
化学属性
| Mol. Weight | 400.4548 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | GNE-317 |
|---|---|
| Formula | C18H20N6O3S |
| Synonym | GNE317; GNE 317; GNE-317. |
| IUPAC Name | 5-(6-(3-methoxyoxetan-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine |
| InChIKey | KBTBHOPRFNFYOA-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H20N6O3S/c1-25-18(9-27-10-18)13-6-12-14(28-13)16(24-2-4-26-5-3-24)23-15(22-12)11-7-20-17(19)21-8-11/h6-8H,2-5,9-10H2,1H3,(H2,19,20,21) |
| Canonical SMILES | NC1=NC=C(C2=NC(N3CCOCC3)=C4C(C=C(C5(OC)COC5)S4)=N2)C=N1 |
| Chemical Name Translation | GNE-317游离态 |
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产品应用
- GNE-317 is a potent and selective PI3K inhibitor with potential anticncer activity. GNE-317 targets the PI3K pathway and can cross the Blood–Brain Barrier. GNE-317 was identified as having physicochemical properties predictive of low efflux by P-gp and BCRP. Studies in transfected MDCK cells showed that GNE-317 was not a substrate of either transporter. GNE-317 markedly inhibited the PI3K pathway in mouse brain, causing 40% to 90% suppression of the pAkt and pS6 signals up to 6-hour postdose.
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