(Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride (Z)-11-[3-(二甲基氨基)亚丙基]-6,11-二氢二苯并[b,e]氧杂卓-2-乙酸盐酸盐

CAS 140462-76-6 MFCD00875716

化学结构图

140462-76-6
SMILES: Cl.CN(C)CC/C=C1\c2cc(CC(O)=O)ccc2OCc2ccccc2\1

化学属性

Mol. FormulaC21H23NO3.HCl
Mol. Weight373.88

别名和识别编码

Chemical Name(Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride
Synonym Olopatadine hydrochloride
MDL NumberMFCD00875716
CAS Number140462-76-6
Reaxys-RN6675608
PubChem Substance ID87561038
Merck Number6840
InChIKeyJBIMVDZLSHOPLA-LSCVHKIXSA-N
Chemical Name Translation(Z)-11-[3-(二甲基氨基)亚丙基]-6,11-二氢二苯并[b,e]氧杂卓-2-乙酸盐酸盐
Beilstein Registry Number6675608
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分类

  • {SNA} Analytical Standards, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards N - O, 分析/色谱
  • {SNA} Bioactive Small Molecule Alphabetical Index, O, 生物活性小分子, 细胞生物学
  • {SNA} Bioactive Small Molecules, Cell Biology, O

相关文献及参考

  • [2]. Ohmori, K., et al., Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug. Jpn J Pharmacol, 2002. 88(4): p. 379-97.
  • [3]. Yanni, J.M., et al., The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent. J Ocul Pharmacol Ther, 1996. 12(4): p. 389-400.
  • [1]. Tamura, T., et al., Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Pharmacology, 2005. 75(1): p. 45-52.
  • [1]. Tamura, T., et al., Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Pharmacology, 2005. 75(1): p. 45-52.
  • [2]. Ohmori, K., et al., Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug. Jpn J Pharmacol,

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
Hazard statements
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H301 Toxic if swallowed 吞食有毒
Signal word
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard Codes T,N
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R50 Very toxic to aquatic organisms 对水生生物极毒
RTECSHQ4135060
UN Number
Packing GroupIII

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. O - Bioactive Small Molecules
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

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