Vinblastine Sulfate 硫酸长春碱

CAS 143-67-9 MFCD00082457

化学结构图

143-67-9
SMILES: CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1.O=S(=O)(O)O

化学属性

Mol. Weight909.05
Mol. FormulaC46H58N4O9·H2SO4
Melting Point267
TSCANo
Density1.37
SolubilityH2O: 10 mg/mL
Appearance powder

别名和识别编码

MDL NumberMFCD00082457
CAS Number143-67-9
Synonym 29060le Lemblastine Sulfate, Vinblastine VINBLASTINE SULFATE VINBLASTINE SULFATE 98+% BP USP VINBLASTINE SULFATE CRYST VINBLASTINE SULFATE SALT VINBLASTINE SULFATE, CRYSTALLIZED VINBLASTINE SULPHATE VINCALEUKOBLASTINE VINCALEUKOBLASTINE SULFATE VINCALEUKOBLASTINE SULFATE SALT VLB VLB Vinblastine sulfate salt Vincaleukoblastine sulfate salt VLB Vincaleukoblastine sulfate salt Velban Velbe Vinblastin Hexal Vinblastin Sulfate Vinblastina Lilly Vinblastine Vinblastine Sulfate Vinblastine Sulfate USP XXI Vinblastine sulfate salt Vinblastine sulfate, 96.0-102.0% Vinblastinsulfat-Gry Vincaleukblastine sulfate Vincaleukoblastin
PubChem Substance ID241902
EC Number205-606-0
Beilstein Registry Number3659812
Chemical NameVinblastine Sulfate
Merck Number14,9982
Chemical Name Translation硫酸长春碱
InChIInChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
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分类

  • {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antitumor Agents, Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Eli Lilly, Enzymes, Inhibitors, and Substrates, Inhibitors, L - Z, Microtubule Inhibitors, Spectrum of Activity, Substrates, V,
  • {SNA} Analytical Standards,

相关文献及参考

  • [2]. Pandya P, et al. Molecular recognition pattern of cytotoxic alkaloid vinblastine with multiple targets. J Mol Graph Model. 2014 Nov;54:1-9.
  • [3]. Calvi?o E, et al. JNK and NFκB dependence of apoptosis induced by vinblastine in human acute promyelocytic leukaemia cells. Cell Biochem Funct. 2015 Jun;33(4):211-9.
  • [4]. Selimovic D, et al. Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms. Apoptosis. 2013 Aug;18(8):980-97.
  • [5]. Bánóczi Z, et al. Synthesis and in vitro antitumor effect of vinblastine derivative-oligoarginine conjugates. Bioconjug Chem. 2010 Nov 17;21(11):1948-55.
  • Merck: 14,9982
  • Merck: 14,9982 Beilstein: 26,IV,3167
  • [1]. McKay DB, et al. Nicotinic and nonnicotinic
  • [1]. McKay DB, et al. Nicotinic and nonnicotinic receptor-mediated actions of vinblastine. Proc Soc Exp Biol Med. 1993 Jul;203(3):372-6.

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P308+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSYY8400000
Hazard Codes 6.1 Xn Xn,T
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S36/39 Wear suitable protective clothing and eye/face protection 穿戴适当的防护服和眼睛/面保护；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Storage condition 存储温度2-8℃ 2-8°C
Packing GroupII
Hazard Class6.1(a)
UN Number 1544

其他信息

  • EPA Substance Registry System:143-67-9(EPA Substance)
  • 用途一:抗肿瘤药，用于治疗何杰金氏病和绒毛膜上皮癌，对淋巴肉瘤、急性白血病、乳腺癌等也有一定疗效
  • 硫酸长春碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 203450250 硫酸长春碱 Vinblastine sulfate 96.0-102.0% 25 MG 3330元 2010/06/21 203450050 硫酸长春碱 Vinblastine sulfate 96.0-102.0% 5 MG 966元
  • 用途二:抗肿瘤药，用于恶性淋巴瘤。
  • 水溶性:＞=1 g/100 mL at 24.5℃
  • color:white
  • 比旋光度:-21.7 ° (c=2, CH3OH 21 °C)
  • MOL 文件:143-67-9.mol
  • F:8-10
  • 下游产品:硫酸长春地辛

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics T-Z - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Spectrum of Activity - Antibiotics
  4. Antibacterial - Spectrum of Activity
  5. L - Z - Antibacterial
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Antibiotics by Application
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Xenobiotics and Drug Metabolism
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Spectrum of Activity
  5. Antibacterial
  6. A - K
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Cytoskeleton and Extracellular Matrix
  5. Extracellular Matrix
  6. Angiogenesis Regulators
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Cytoskeleton and Extracellular Matrix Proteins
  6. Extracellular Matrix
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Xenobiotics and Drug Metabolism
  6. Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Cytoskeleton and Extracellular Matrix Proteins
  6. Extracellular Matrix
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Proteins for Cell Biology
  6. Apoptosis and Cell Cycle Proteins
  7. Apoptosis Inhibitors
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Microtubule/Tubulin  (微管/微管蛋白)

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