Deflazacort 地氟可特

CAS 14484-47-0 MFCD00866106

化学结构图

14484-47-0
SMILES: CC(=O)OCC(=O)[C@@]12N=C(C)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]21C

化学属性

Mol. FormulaC25H31NO6
Mol. Weight441.52
Melting Point252-258

别名和识别编码

Chemical NameDeflazacort
CAS Number14484-47-0
Synonym Deflazacort 11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate Calcort Dezacort azacort L-5458 L 5458 DL-458-IT Deflan (11?,16?)-21-(Acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 11β,21-dihydroxy-2'-methyl-5'βH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 2'-acetate (11β,16β)-21-(acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione Lantadin oxazacort (11β,16β)-21-(acetyloxy)-11-hydroxy-2′-methyl-5′H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione (11β,16β)-21-(acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 11β,21-dihydroxy-2'-methyl-5'βH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 2'-acetate DL-458-IT L-5458 azacort oxazacort pregna-1,4-diene-11β,21-diol-3,20-dione[17α,16α-d]-2'-met
MDL NumberMFCD00866106
EC Number238-483-7
Chemical Name Translation地氟可特
Wiswesser Line NotationT F5 E5 B666 GN IO RV GU AHTTTT&J A1 CQ E1 FV1OV1 H1
PubChem Substance ID253661789
Reaxys-RN4947650
Merck Number2862
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Corticosteroid, Cytokines, Growth Factors and Hormones, D-DIF, Hormones, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, D-DIF, Hormones, Steroid Hormones

产品应用

  • A systemic corticosteroid. A derivative of prednisolone. Used for rheumatoid arthritis and lupus.

相关文献及参考

  • Archer JD, Vargas CC, Anderson JE., Persistent and improved functional gain in mdx dystrophic mice after treatment with L-arginine and deflazacort. FASEB J. 6 , 738-40, (2006)
  • Cavall-Perin, P., et al.: Eur. J. Clin. Pharmacol., 26, 357 (1984),
  • Nathansohn, G., et al.: J. Med. Chem., 10,799 (1967),
  • Schiatti, P., et al.: Arzneim. Forsch., 30, 1543 (1980),
  • Vandenburgh H, Shansky J, Benesch-Lee F, Skelly K, Spinazzola JM, Saponjian Y, Tseng BS., Automated drug screening with contractile muscle tissue engineered from dystrophic myoblasts. FASEB J. 10 , 3325-34, (2009)
  • [1]. Mollmann, H., et al., Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone. Pharmaceutical research, 1995. 12(7): p. 1096-1100.

安全信息

WGK Germany3
GHS Symbol
Safety Statements
Precautionary statements
RTECSTU4157050 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,1543,1980

Storage condition 0-10°C

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Corticosteroid - Steroid Hormones
  1. Functional Group 官能团索引
  2. imido ester
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Glucocorticoid Receptor  (糖皮质激素受体)

相关产品推荐