Rosuvastatin Calcium 瑞舒伐他汀钙

CAS 147098-20-2 MFCD00953841

化学结构图

147098-20-2
SMILES: [Ca+2].CS(=O)(=O)N(C)C1=NC(C(C)C)=C(/C=C/[C@@H](O)C[C@@H](O)CC([O-])=O)C(=N1)C1C=CC(F)=CC=1.CS(=O)(=O)N(C)C1=NC(C(C)C)=C(/C=C/[C@@H](O)C[C@@H](O)CC([O-])=O)C(=N1)C1C=CC(F)=CC=1 |&1:16,19,49,52|

化学属性

Mol. FormulaC22H27FN3O6S?1/2Ca
Mol. Weight500.57

别名和识别编码

Chemical NameRosuvastatin Calcium
CAS Number147098-20-2
Synonym (3R,5S,6E)-
Chemical Name Translation瑞舒伐他汀钙
LabNetwork Molecule IDLN01327270
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分类

  • Aromatics
  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • A selective, competitive HMG-CoA reductase inhibitor. Antilipemic.

相关文献及参考

  • [2]. Carswell C.I., et al. Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7.
  • [3]. Plante I, et al. Rosuvastatin blocks hERG current and prolongs cardiac repolarization. J Pharm Sci. 2012 Feb;101(2):868-78.
  • [4]. Feng PF, et al. Intracellular Mechanism of Rosuvastatin-Induced Decrease in Mature hERG Protein Expression on Membrane. Mol Pharm. 2019 Apr 1;16(4):1477-1488.
  • Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006),
  • Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005),
  • Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997),
  • [1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrol
  • [1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44.

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. HMG-CoA Reductase (HMGCR)  (HMG-CoA还原酶)

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