3,4-Methylenedioxyphenethylamine 胡椒乙胺

CAS 1484-85-1 MFCD00060509

化学结构图

1484-85-1
SMILES: NCCc1ccc2c(c1)OCO2

化学属性

Mol. FormulaC9H11NO2
Mol. Weight165
Density1.422

别名和识别编码

Chemical NameHomopiperonylamine
CAS Number1484-85-1
Alfabeta NameMETHYLENEDIOXYPHENETHYLAMINE 34-,
MDL NumberMFCD00060509
Synonym 1,3-BENZODIOXOLE-5-ETHANAMINE 1,3-BENZODIOXOLE-5-ETHYLAMINE 1,3-Benzodioxole-5-ethanamine 2-(3',4'-METHYLENEDIOXY-PHENYL)ETHYLAMINE 2-(3,4-(METHYLENDIOXY)PHENYL)ETHYLAMINE 2-(3,4-METHYLENEDIOXYPHENYL)ETHYLAMINE(HOMOPIPERONYLAMINE) 2-(3,4-Methylenedioxyphenyl)Et 2-(3,4-亚甲二氧苯基)乙胺 3,4-(METHYLENEDIOXYPHENYL)ETHYLAMINE 3,4-(METHYLENEDIOXYPHENYL)ETHYLAMINE 95% 3,4-MDE 3,4-METHYLENEDIOXYPHENETHYLAMINE 3,4-Methylenedioxyphenethylamine 3,4-methylenedioxy-phenethylamin 3,4-methylenedioxyphenethylamine 3,4-亚甲二氧苯乙胺 5-(2-Aminoethyl)benzodioxole AURORA KA-7750 DL-MDEA HCl of 3,4-methylenedioxyphenethylamine HOMOPIPERONYLAMINE Homopiperonylamine ,97% Homopiperonylamine=
EC Number250-023-7
Beilstein Registry Number0383838
Chemical Name Translation胡椒乙胺
InChIKeyRRIRDPSOCUCGBV-UHFFFAOYSA-N
Wiswesser Line NotationT56 BO DO CHJ G2Z
PubChem Substance ID73874
LabNetwork Molecule IDLN00173233
InChIInChI=1S/C9H11NO2/c10-4-3-7-1-2-8-9(5-7)12-6-11-8/h1-2,5H,3-4,6,10H2
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分类

  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Amines, Building Blocks, C9, Chemical Synthesis, Ethers, Nitrogen Compounds, Organic Building Blocks, Oxygen Compounds
  • Metabolites & Impurities
  • Amines

产品应用

  • A metabolite of Dopamine analogs

相关文献及参考

  • Goodwin, B.L

安全信息

Warnings IRRITANT
Signal word Danger Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P302+P352
  • P302+P361+P354
  • P304+P340
  • P305+P351+P338
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P316
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSSH9670000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JPHYA7 Journal of Physiology.  (Cambridge Univ. Press, 32 E. 57th St., New
   York, NY 10022) V.1-    1878-  Volume(issue)/page/year: 76,224,1932

Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi

其他信息

  • 上游原料:4-氯苯甲醛 --> 乙醇溶液 --> 1-氨基乙醇 --> 1,3-苯并二氧杂环戊烯-5-乙腈 --> 利血平 --> 镍触媒 --> 胡椒乙胺
  • MOL 文件:1484-85-1.mol
  • 用途一:该品是医药黄连素和多马胺的中间体。
  • 方法一:由胡椒乙腈或胡椒乙叉亚胺经催化加氢制得。将胡椒乙太亚胺、乙醇、镍触媒如入高压釜。用氮置换釜内空气后通入氨气，再通氢。控制压力3-4MPa、温度95-100℃，氢化反应进行至不再吸氢时算起，继续保温、保持氢压30min。冷却至30℃，降压静置，利用釜内余压出料过滤，除去镍触媒（浸入乙醇套用）。滤液先在常压蒸馏回收氨乙醇溶液，再进行减压蒸馏，收集110-140℃（1.33kPa）馏分，得胡椒乙胺。收率80%。采用胡椒乙腈生产时，工艺过程相仿，温度为80-85℃，压力为1MPa左右。得到含量为92-94%的胡椒乙胺。原料消耗定额：胡椒乙腈1050kg/t、兰尼镍23.4kg/t、氢70kg/t、乙醇（99%）982kg/t。

系列性分类

  1. C9 - Amines

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