(R)-2-(2-((R)-1-(4-Chlorophenyl)-1-Phenylethoxy)Ethyl)-1-Methylpyrrolidine Fumarate (R)-2-(2-((R)-1-(4-氯苯基)-1-苯乙氧基)乙基)-1-甲基吡咯烷富马酸盐

CAS 14976-57-9 MFCD00137486

化学结构图

14976-57-9
SMILES: CN1CCC[C@@H]1CCO[C@](C)(C1C=CC=CC=1)C1C=CC(Cl)=CC=1.OC(=O)/C=C/C(O)=O

化学属性

Mol. FormulaC21H26ClNO · C4H4O4
Mol. Weight459.96

别名和识别编码

Chemical Name(R)-2-(2-((R)-1-(4-Chlorophenyl)-1-Phenylethoxy)Ethyl)-1-Methylpyrrolidine Fumarate
CAS Number14976-57-9
Synonym Aloginan fuluminol ######## (+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrroli lacretin Anhistan CLEMASTINE FUMARATE (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine but-2-enedioic acid agasten anhistan (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt Meclastine fumarate salt Mecloprodine Agasten aloginan clemastinehydrogenfumarate (+)-2-(2-((p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methyl 1-methyl-2-(2-(methyl-p-chlorodiphenylmethyloxy)ethyl)pyrrolidine Clemastine fumarate salt (+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrro (2R)-2-[2-[(1R)-1-(4-CHLOROPHENYLETHOXY)]ETHYL]-1-METHYL-2-PYRROLIDINE FUMARATE (+)-lfumarate(1:1) kinotomin Alphamin lecasol CLEMASTINE FUMARATE SALT inbestan alphamin clemanil 2-(2-(1-(4-chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine hs592
MDL NumberMFCD00137486
PubChem Substance ID24278344
EC Number239-055-2
Chemical Name Translation(R)-2-(2-((R)-1-(4-氯苯基)-1-苯乙氧基)乙基)-1-甲基吡咯烷富马酸盐
Wiswesser Line NotationT5NTJ A1 B2OX1&R&R DG &QV1U1VQ -T
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分类

  • {SNA} Antagonists, Bioactive Small Molecule Alphabetical Index, CI-CZ, Histaminergics, Neuroscience, Neurotransmission, Neurotransmitters, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Chiral Reagents
  • Heterocycles
  • {SNA} Antagonists, Cell Biology, Cell Signaling and Neuroscience, Histaminergics, Neuroscience, Neurotransmission, Neurotransmitters, New Products
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Aromatics

产品应用

  • H1 Histamine receptor antagonist. Antihistaminic.

相关文献及参考

  • [2]. Schran, H.F., et al., The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations. J Clin Pharmacol, 1996. 36(10): p. 911-22.
  • Weidmann, et al.: Boll. Chim. Farm., 106, 467 (1967),
  • [1]. Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42(2): p. 227-34.
  • [1]. Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42(2): p. 227-34.
  • [2]. Schran, H.F., et al., The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations. J Clin Pharmacol, 1996. 36(10): p. 911-22.

安全信息

WGK Germany3
RTECSUY0704600
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 730 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   106,467,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - muscle contraction or spasticity
   Gastrointestinal - nausea or vomiting
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   106,467,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,230,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >50 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - muscle contraction or spasticity
   Gastrointestinal - nausea or vomiting
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(i

GHS Symbol
Signal word Warning
Precautionary statements

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Histaminergics - Neurotransmitters
  8. Antagonists - Histaminergics
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

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