4-Methoxyphenol 对羟基苯甲醚

CAS 150-76-5 MFCD00002332

化学结构图

150-76-5
SMILES: COc1ccc(O)cc1

化学属性

Mol. FormulaC7H8O2
Mol. Weight124.14
Autoignition Point789 °F
Vapor Density4.3 (vs air)
Boiling Point243°C at 760 mmHg
Vapor Pressure<;0.01 mmHg ( 20 °C)
Melting Point56°C
Density1.5502
Flash Point>110°C
TSCAYes
Refractive index1.551-1.553
Solubility微溶于水。
Stability对光敏感
pH:A

别名和识别编码

Chemical Name4-Methoxyphenol
CAS Number150-76-5
Alfabeta NameMETHOXYPHENOL 4-
MDL NumberMFCD00002332
Synonym Mequinol {LY} Mequinol {} {LY} Mequinol {} {} {LY} Mequinol {} {} {} {LY} Mequinol {} {} {} {} {LY} Mequinol {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {} {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Mequinol {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID9015
EC Number205-769-8
Beilstein Registry Number507924
Chemical Name Translation对羟基苯甲醚
Reaxys-RN507924
Wiswesser Line NotationQR DO1
LabNetwork Molecule IDLN00174589
InChIInChI=1S/C7H8O2/c1-9-7-4-2-6(8)3-5-7/h2-5,8H,1H3
Canonical SMILESOC(C=C1)=CC=C1OC
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分类

  • {SNA} Building Blocks, C6 to C8, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Phenols

产品应用

  • 溶剂。用作乙烯基型塑料单体的阻聚剂；紫外线抑制剂；染料中间体及用于合成食用油脂和化妆品的抗氧化剂BHA（3-特丁基-4-羟基苯甲醚）等。它最大的优点是添加MEHQ后的单体和其它单体共聚时不必除去，可三元直接共聚，还可用作防老剂、抗氧剂等。

相关文献及参考

  • For a study of the direct dilithiation of alkoxyphenols, see: J. Org. Chem., 55, 3902 (1990).
  • Primary OH groups can be protected as 4-methoxyphenyl ethers by Mitsunobu alkylation. These are stable to aqueous acid or base at 1000, high pressure hydrogenation, ozonolysis, LiAlH4, or Cr(VI) reagents. Deprotection can be effected with CAN: Tetrahedron Lett., 26, 6291 (1985); 29, 1389 (1988), or anodic oxidation: Carbohydr. Res., 277, 321 (1995).
  • Beilstein:6,843

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany1
Hazard statements
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSSL7700000
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P302+P352+P333+P313+P362+P364
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P305+P351+P338+P337+P313
  • P301+P312+P330
  • P308+P313
  • P337+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P333+P313
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
Signal word
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R22 Harmful if swallowed 吞咽有害
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Hazard Codes Xn
UN Number 2810
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KODAK* Kodak Company Reports.  (343 State St., Rochester, NY 14650)
   Volume(issue)/page/year: 21MAY1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 25 umol/L
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 54,133,1986

其他信息

  • 用途二:用作乙烯基型塑料单体的阻聚剂、紫外线抑制剂、染料中间体及用于合成食用油脂和化妆品的抗氧化剂BHA（3-特丁基-4-羟基苯甲醚）等。
  • TCI Shanghai:4-甲氧基苯酚 4-Methoxyphenol,>;99.0%(GC)(150-76-5)
  • 毒性分级:中毒
  • 下游产品:N-异丙基丙烯酰胺 --> 叔丁基-4-羟基苯甲醚 --> 5-甲氧基苯并呋喃 --> 5-甲氧基苯并呋喃-2-甲酸 --> 5-甲氧基水杨酸 --> 2-羟基-5-甲氧基苯甲醛 --> 分散红146
  • 职业标准:TWA 5 毫克/立方米； STEL 10 毫克/立方米
  • 图谱信息:4-甲氧基苯酚(150-76-5)质谱(MS) 4-甲氧基苯酚(150-76-5)核磁图( 13 CNMR) 4-甲氧基苯酚(150-76-5)核磁图( 1 HNMR) 4-甲氧基苯酚(150-76-5)红外图谱(IR1) 4-甲氧基苯酚(150-76-5)红外图谱(IR2) 4-甲氧基苯酚(150-76-5)Raman光谱
  • 灭火剂:水, 二氧化碳, 干粉, 砂土
  • 刺激数据:皮肤-兔 6000 毫克/12天 轻度
  • 方法一:以对苯二酚为原料，用硫酸二甲酯作甲基化剂，或者在高温高压和催化下用甲醇作甲基化剂，均可制得4-甲氧基酚。另一种较新的方法是，在存在对苯醌的条件下由对苯二酚与甲醇反应。将甲醇和浓硫酸混合均匀，加入对苯二酚，加热回流，滴加对苯醌的甲醇溶液反应3h。冷却，用40%氢氧化钠溶液中和，滤除硫酸钠沉淀。滤液回收甲醇后用乙醚萃取，萃取液蒸去乙醚，再进行减压蒸馏，收集110-112℃（0.53kPa）馏分即得成品。收率为76%。
  • Alfa Aesar:4-甲氧基苯酚,98+% 4-Methoxyphenol, 98+%(150-76-5)
  • 易溶于乙醇、乙醚、丙酮、苯和乙酸乙酯，微溶于水。有毒。有刺激性。
  • MSDS 信息:对甲氧基苯酚(150-76-5).msds
  • Acros Organics:4-甲氧基苯酚/对羟基苯甲醚 4-Methoxyphenol, stabilized, pure,
  • 蒸气密度:4.3 (vs air)
  • MOL 文件:150-76-5.mol
  • 类别:有毒物质
  • 4-甲氧基苯酚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30114726 4-甲氧基酚;对羟基苯甲醚;氢醌单甲醚对甲氧基苯酚 100g 44.3元 2011/04/16 M0123 4-甲氧基苯酚 4-Methoxyphenol 25G 150元 2011/04/16 M0123 4-甲氧基苯酚 4-Methoxyphenol 500G 580元
  • 海关编码:29095090
  • 外观性质:淡色固体, 有焦饴糖和酚的气味。
  • Sigma Aldrich:150-76-5(sigmaaldrich)
  • 蒸气压:<;0.01 mm Hg ( 20 °C)
  • 用途一:主要用于乙烯基型塑料单体的阻聚剂、紫外线抑制剂、染料中间体及用于合成食用油脂和化妆品抗氧化剂BHA等
  • 用途三:溶剂。用作乙烯基型塑料单体的阻聚剂；紫外线抑制剂；染料中间体及用于合成食用油脂和化妆品的抗氧化剂BHA（3-特丁基-4-羟基苯甲醚）等。它最大的优点是添加MEHQ后的单体和其它单体共聚时不必除去，可三元直接共聚，还可用作防老剂、抗氧剂等。
  • 急性毒性:口服- 大鼠 LD50: 1600 毫克/ 公斤; 腹腔- 小鼠 LD50: 250 毫克/ 公斤
  • 上游原料:乙醇 --> 甲醇 --> 硫酸 --> 1,4-苯二酚 --> 甲醇溶液 --> 苯醌 --> 对苯
  • 可燃性危险特性:可燃; 火场释放辛辣刺激烟雾
  • 储运特性:库房低温, 通风, 干燥 ; 防火; 与强氧化剂分开存放

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Oxidation - Synthetic Reagents
  4. Sulfur-Based - Oxidation
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols 酚类
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols 酚类
  6. C6 to C8 - Phenols
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Aromatic alcohols 芳香醇
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Ethers
  1. Materials Science 材料科学
  2. Building Blocks for Liquid Crystals

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