GR 231118
CAS 158859-98-4 MFCD00927773
化学结构图
SMILES: CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1C=CC(O)=CC=1)NC(=O)C1CNC(=O)CC[C@H](NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N2CCC[C@H]2C(=O)NC(CNC(=O)CC[C@H](NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1C=CC(O)=CC=1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1C=CC(O)=CC=1)C(N)=O
化学属性
| Mol. Formula | C110H170N34O24 |
|---|---|
| Mol. Weight | 2352.77 |
别名和识别编码
| Chemical Name | GR 231118 |
|---|---|
| Synonym | 1229U91 1229U91 Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2, cyclic (2,4')(2',4) diamide Neuropeptide Y Antagonist GR 231118 Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2, cyclic (2,4′)(2′,4) diamide Neuropeptide Y Antagonist |
| MDL Number | MFCD00927773 |
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分类
- Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G, Gastrointestinal Peptides, Neuropeptide Y, Neuropeptide Y and Peptide YY, Neuropeptide Y and Peptide YY Peptides, Neuropeptides, Neurotransmission (Obesity), Obesity Research, Peptides and Proteins, Peptides for Cell Biology
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G, Gastrointestinal Peptides, Neuropeptide Y, Neuropeptide Y and Peptide YY, Neuropeptide Y and Peptide YY Peptides, Neuropeptides, Neurotransmission (Obesity), Obesity Research,
相关文献及参考
- [2]. Y Dumont, et al. [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol. 2000 Jan;129(1):37-46.
- Angus, J.A., new insights into vascular reactivity: from altered structure to neural control. Clin. Exp. Pharmacol. Physiol. 24 , 297-304, (1997) 摘要
- Kennedy, B., et al., Neuropeptide Y-mediated pressor responses following high-frequency stimulation of the rat sympathetic nervous system. J. Pharmacol. Exp. Ther. 281 , 291-296, (1997) 摘要
- [1]. E M Parker, et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol
- [1]. E M Parker, et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol
- [2]. Y Dumont, et al. [(125)I]-GR2
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