4-Iodo-3-Nitrobenzamide 3-硝基-4-碘苯甲酰胺
CAS 160003-66-7 MFCD11110639
化学结构图
SMILES: NC(=O)c1ccc(I)c([N+](=O)[O-])c1
化学属性
| Mol. Formula | C7H5IN2O3 |
|---|---|
| Mol. Weight | 292.03067 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not soluble in water. |
别名和识别编码
| Chemical Name | 4-Iodo-3-Nitrobenzamide |
|---|---|
| CAS Number | 160003-66-7 |
| Alfabeta Name | IODONITROBENZAMIDE 43--- |
| MDL Number | MFCD11110639 |
| Synonym | 4-Iodo-3-nitrobenzamide BSI 201 BSI-201; BSI201; BSI 201; NSC746045; NSC-746045; NSC 746045; ND-71677; NIBA; INO-2BA; SAR-240550; Iniparib |
| Chemical Name Translation | 3-硝基-4-碘苯甲酰胺 |
| Formula | C7H5IN2O3 |
| IUPAC Name | 4-iodo-3-nitrobenzamide |
| InChIKey | MDOJTZQKHMAPBK-UHFFFAOYSA-N |
| InChI | InChI=1S/C7H5IN2O3/c8-5-2-1-4(7(9)11)3-6(5)10(12)13/h1-3H,(H2,9,11) |
| Canonical SMILES | O=C(N)C1=CC=C(I)C([N+]([O-])=O)=C1 |
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分类
- Aromatics
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Iniparib, also known as SAR-240550; NSC-746045; BSI-201; IND-71677; NIBA; INO-2BA, is a small-molecule prodrug inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) with potential chemosensitizing, radiosensitizing and antineoplastic activities. In vivo, PARP-1 inhibitor BSI-201 is converted to the active drug, which selectively binds to PARP-1 and inhibits PARP-1- mediated DNA repair. Consequently, this agent may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. In addition, PARP-1 inhibitor BSI-201 may exhibit direct antineoplastic activity against cancers defective in DNA repair.
相关文献及参考
- Liang, H. et al.: IDrugs, 13, 646 (2010); Liang, H. et al.: Curr. Breat Cancer Rep., 3, 44 (2011); O'Shaughnessy, J. et al.: N. Eng. J. Med., 364, 205 (2011);
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