2-Hydroxy Atorvastatin Lactone

CAS 163217-74-1 MFCD63217741

化学结构图

163217-74-1
SMILES: [2H]C1=C(C2C(=C(C(C)C)N(CC[C@@H]3C[C@@H](O)CC(=O)O3)C=2C2C=CC(F)=CC=2)C(=O)NC2=CC=CC=C2O)C([2H])=C([2H])C([2H])=C1[2H]

化学属性

Mol. Weight556.62
Mol. FormulaC33H33FN2O5

别名和识别编码

CAS Number163217-74-1
Chemical Name2-Hydroxy Atorvastatin Lactone
Synonym 5-(4-Fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
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分类

  • Metabolites,

产品应用

  • A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and trig

相关文献及参考

  • [2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.
  • [1]. Guo CX, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012;42(8):784‐790.
  • [1]. Guo CX, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012;42(8):784‐790.
  • [2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Drug Metabolite  (药物代谢物)

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