1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, benzilate(ester), hydrochloride 内-8-甲基-8-氮杂二环[3.2.1]辛-3-基-2-羟基-2,2-二苯基乙酸酯

CAS 1674-94-8 MFCD01677440

化学结构图

1674-94-8
SMILES: CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2.Cl

化学属性

Mol. FormulaC22H25NO3.ClH
Mol. Weight387.94
Melting Point244 ºC

别名和识别编码

Chemical Name盐酸盐 Endo-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl-2-hydroxy-2,2-diphenylacetate hydrochloride
Synonym Benzilsaeure-tropinester hydrochlorid Tropine benzilate hydrochloride Benzilic acid 3alpha-tropanyl ester hydrochloride; 1alphaH,5alphaH-Tropan-3alpha-ol benzilate (ester) hydrochloride 3-Tropyl benzilate hydrochloride
CAS Number1674-94-8
Chemical Name Translation内-8-甲基-8-氮杂二环[3.2.1]辛-3-基-2-羟基-2,2-二苯基乙酸酯
PubChem Substance ID3084624
InChIInChI=1S/C22H25NO3.ClH/c1-23-18-12-13-19(23)15-20(14-18)26-21(24)22(25,16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18-20,25H,12-15H2,1H3;1H/t18-,19+,20?;
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安全信息

RTECSYM4151000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 7,217,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 13680 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 120,160,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 92580 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 120,160,1959

系列性分类

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