Acridine Mutagen Icr 191 吖啶诱变剂ICR191

CAS 17070-45-0 MFCD00013320

化学结构图

17070-45-0
SMILES: Cl.Cl.COC1=CC2=C(NCCCNCCCl)C3=CC=C(Cl)C=C3N=C2C=C1

化学属性

Mol. FormulaC19H21Cl2N3O · 2HCl
Mol. Weight451.22

别名和识别编码

Chemical NameAcridine Mutagen Icr 191
Synonym 2-Methoxy-6-chloro-9-(3-(2-chloroethyl)aminopropylamino) acridine, 6-Chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride Acridine Mutagen ICR 191 ICR dihydrochloride ICR-191 ICR-191A
MDL NumberMFCD00013320
PubChem Substance ID24896042
Beilstein Registry Number8176205
CAS Number17070-45-0
EC Number241-129-4
Chemical Name Translation吖啶诱变剂ICR191
Wiswesser Line NotationT C666 BNJ EG IM3M2G LO1 &GH 2
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分类

  • Alphabetical, Biochemicals and Reagents, Fluorescent Probes, Labels, Particles and Stains, Fluorescent Stains, Luminescent Compounds/Detection, Nucleic Acid Stains, Stains and Dyes
  • {SNA} Alphabetical, Fluorescent Stains, Nucleic Acid Stains, Stains and Dyes, 发光化合物及其检测, 生化试剂, 荧光探针,标记,粒子和染色剂
  • {SNA} Alphabetical, Biochemicals and Reagents, Fluorescent Probes, Labels, Particles and Stains, Fluorescent Stains, Nucleic Acid Stains

相关文献及参考

  • Ames, B.N., et al. Proc. Natl. Acad. Sci. U. S. A. 70 , 782, (1973) 摘要

安全信息

RTECSAR7678000
WGK Germany3
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Hazard statements
  • H350 May cause cancer 可能致癌
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H300 Fatal if swallowed 吞食致命
Hazard Codes T+
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Signal word Danger
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Risk Statements
  • R46 May cause inheritable genetic damage 可能引起遗传基因损害
  • R45 May cause cancer 可能致癌
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有剧毒
TYPE OF TEST            : LD20 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 41 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,739,1972

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Serratia marcescens
DOSE/DURATION           : 1 gm/L
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year: 28,93,1971

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,11,1981

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Haemophilus influenzae
DOSE/DURATION           : 250 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 80,249,1981

{haz

TYPE OF TEST            : Mutation in mamm

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 700 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,81,1988

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ng/plate
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United State

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 1 umol/L/3H
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 16,284,1975

系列性分类


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