Lisuride
CAS 18016-80-3 MFCD00153872
化学结构图
SMILES: CN1C[C@H](C[C@H]2[C@H]1CC1=CNC3C=CC=C2C1=3)NC(=O)N(CC)CC.OC(=O)/C=C\C(O)=O
化学属性
| Mol. Formula | C20H26N4O |
|---|---|
| Mol. Weight | 456.53 |
别名和识别编码
| Chemical Name | Lisuride |
|---|---|
| CAS Number | 18016-80-3 |
| Synonym | ######## S(–)-N,N-Diethyl-N′-[(8a)-6-methylergolin-8-yl]urea |
| MDL Number | MFCD00153872 |
| EC Number | 253-625-8 |
| Chemical Name Translation |
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分类
- Agonists
- Heterocycles
- Neurochemicals
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Agonists, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics, Neuroscience, Neurotransmission, Neurotransmitters
产品应用
- A dopamine and serotonin receptor partial agonist with high affinity for the dopamine D2, D3 and D4 receptors, as well as serotonin 5-HT1A and 5-HT2A/C receptors. An anti-parkinson agent.
相关文献及参考
- [2]. Kehr W. Effect of lisuride and other ergot derivatives on monoaminergic mechanisms in rat brain. Eur J Pharmacol. 1977;41(3):261-273.
- De Keyser, J. et al.: Prog. Neuro-Psychopharmacol. Biol. Psych., 19, 1147 (1995); Bakker, R.A. et al.: Mol. Pharmacol., 65, 1048 (2004); Woitalla, D. et al.: J. Neural Trans. Supp., 68, 89 (2004);
- [1]. Rinne UK. Lisuride, a dopamine agonist in the treatment of early Parkinson's disease. Neurology. 1989;39(3):336-339.
- [1]. Rinne UK. Lisuride, a dopamine agonist in the treatment of early Parkinson's disease. Neurology. 1989;39(3):336-339.
- [2]. Kehr W. Effect of lisuride and other ergot derivatives on monoaminergic mechanisms in rat brain. Eur J Pharmacol. 1977;41(3):261-273.
安全信息
GHS Symbol
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
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