(3S)-3-(4-AMINO-1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PIPERIDINE-2,6-DIONE 来那度胺

CAS 191732-72-6 MFCD07772307

化学结构图

191732-72-6
SMILES: Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O

化学属性

Mol. FormulaC13H13N3O3
Mol. Weight259
Melting Point269-271°
Appearance White solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name(3S)-3-(4-AMINO-1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PIPERIDINE-2,6-DIONE
Synonym 3-(7-Amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione CC5013; CC-5013; CC 5013; IMiD1; Lenalidomide; US brand name: Revlimid.
Chemical Name Translation来那度胺
CAS Number191732-72-6
Alfabeta NameAMINOOXODIHYDROISOINDOLYLPIPERIDINEDIONE H341132226()------------,,
MDL NumberMFCD07772307
FormulaC13H13N3O3
IUPAC Name3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChIKeyGOTYRUGSSMKFNF-UHFFFAOYSA-N
InChIInChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
Canonical SMILESO=C(C(N(CC1=C2C=CC=C1N)C2=O)CC3)NC3=O
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产品应用

  • Lenalidomide, also known as CC-5013, is the thalidomide analog with potential antineoplastic activity. Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells. Lenalidomide is an approved drug.

安全信息

Signal word Warning
GHS Symbol
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类


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