Propionamide,2-(dimethylamino)-N-(1,3-diphenylpyrazol-5-yl)-

CAS 20170-20-1 MFCD00864379

化学结构图

20170-20-1
SMILES: CN(C)C(C)C(=O)NC1=CC(=NN1C1C=CC=CC=1)C1C=CC=CC=1

化学属性

Mol. FormulaC20H22N4O
Mol. Weight334.46

别名和识别编码

Chemical NamePropionamide,2-(dimethylamino)-N-(1,3-diphenylpyrazol-5-yl)-
Wiswesser Line NotationT5NNJ AR& CR& EMVY1&N1&1
Synonym 2-(Dimethylamino)-N-(1,3-diphenyl-1H-pyrazol-5-yl)propanamide Propanamide, 2-(dimethylamino)-N-(1,3-diphenyl-1H-pyrazol-5-yl)- 1,3-Diphenyl-5-(2-dimethylaminopropionamido)pyrazole Pasalin AP-14 Difenamizole Diphenamizole
Beilstein Registry Number0698538
CAS Number20170-20-1
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安全信息

RTECSUE3865000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1480 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 4,467,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >12819 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 4,467,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 960 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GDIKAN Gifu Daigaku Igakubu Kiyo.  Papers of the Gifu University School of
   Medicine.  (Gifu Daigaku Igakubu, 40 Tsukasa-machi, Gifu 500, Japan)  V.15-
   1967-  Volume(issue)/page/year: 20,360,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 815 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GDIKAN Gifu Daigaku Igakubu Kiyo.  Papers of the Gifu Univers

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