Vincristine Sulfate 硫酸长春新碱

CAS 2068-78-2 MFCD00084729

化学结构图

2068-78-2
SMILES: CC(=O)O[C@@H]1[C@]2(CC)C=CCN3CC[C@]4([C@@H](N(C=O)C5C=C(OC)C(=CC4=5)[C@]4(C[C@@H]5C[C@](O)(CN(C5)CCC5=C4NC4C=CC=CC5=4)CC)C(=O)OC)[C@@]1(O)C(=O)OC)[C@H]23.OS(O)(=O)=O |&1:4,5,14,15,27,29,31,53,59|

化学属性

Mol. FormulaC46H58N4O14S
Mol. Weight923
Melting Point300
Solubility>=1 G/100 ML AT 24 ºC
TSCANo
Boiling Point273-281°
Appearance lyophilized powder

别名和识别编码

Chemical NameVincristine Sulfate
MDL NumberMFCD00084729
CAS Number2068-78-2
Synonym lilly37231 22-OXOVINCALEUKOBLASTINE SULFATE SALT 长春新碱 硫酸醛基长春碱 VCR 醛基长春碱 硫酸盐 长春醛碱 硫酸盐 硫酸长春新碱 LEUROCRISTINE SULFATE VINCRISTINE SULFATE VCR 醛基长春碱 硫酸盐 长春新碱 硫酸盐 长春醛碱 硫酸盐 leurocristinesulfate(1:1) 长春新碱硫化物 硫酸醛基长春碱,硫酸长春醛碱 长春新碱硫酸盐 22-OXOVINCALEUKO-BLASTINE SULFATE VINCRISTINE SULFATE, APOCYNACEAE SPECIES 22-OXOVINCALEUKOBLASTINE 长春地辛 LEUROCRISTINE 硫酸长春醛碱 长春新碱 硫酸酯 VCR kyocristine 22-oxo-vincaleukoblastinsulfate(1:1)(salt) VINCRISTINE SULFATE SAL oncovin
Beilstein Registry Number3924631
EC Number218-190-0
PubChem Substance ID24900771
Merck Number14,9986
Chemical Name Translation硫酸长春新碱
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分类

  • {SNA} Antibacterial, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Core Bioreagents, Enzyme Inhibitors, L - Z, Pharmacopoeia, Pharmacopoeia A-Z, Pharmacopoeial Antibiotics, Research Essentials, Spectrum of Activity, 分析/色谱, 抗生素, 生化试剂
  • {SNA} Analytical Standards,
  • {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Apoptosis and Cell Cycle, Application Index, Biochemicals and Rea

产品应用

  • 广泛地用于癌症研究，多药物抑制，单胺氧化酶（monoamine oxidase）抑制剂。

相关文献及参考

  • [2]. Gidding, C.E., et al, Vincristine revisited. Crit Rev Oncol Hematol, 1999. 29(3): p. 267-87.
  • [3]. Donoso, J.A., et al, Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on axonal fibrillar organelles in vitro. Cancer Res, 1977. 37(5): p. 1401-7.
  • [4]. Horton, J.K., et al. Relationships between tumor responsiveness, vincristine pharmacokinetics and arrest of mitosis in human tumor xenografts. Biochem Pharmacol, 1988. 37(20): p. 3995-4000.
  • [5]. Baguley, B.C., et al, Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism. Eur J Cancer, 1991. 27(4): p. 482-7.
  • [6]. Zhang D, et al. Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance. Int J Nanomedicine. 2017 Mar 16;12:2081-2108.
  • Merck: 14,9986
  • [1]. Jordan, M.A., et al. Comparison of the effects of vinblastine,

安全信息

WGK Germany3
RTECSOH6340000
Hazard Codes T
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R25 Toxic if swallowed 吞咽有毒
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
UN Number UN 2811 6.1/PG 2
GHS Symbol
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H300 Fatal if swallowed 吞食致命
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P310
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Signal word
Packing GroupII
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 2-8°C 存储温度-20℃

其他信息

  • MOL 文件:2068-78-2.mol
  • HazardClass:6.1(a)
  • PackingGroup:II
  • RTECS号:OH6340000
  • 硫酸长春新碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 203440050 硫酸长春新碱 Vincristine sulfate 95% 5 MG 2007元
  • 水溶性:＞=1 g/100 mL at 24℃
  • F:8-10
  • 用途:天然植物抗肿瘤药，用于治疗急性白血病和恶性淋巴瘤，小细胞肺癌及乳腺癌。
  • EPA化学物质信息:Vincaleukoblastine, 22-oxo-, sulfate (1:1) (salt)(2068-78-2)

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics T-Z - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Spectrum of Activity - Antibiotics
  4. Antibacterial - Spectrum of Activity
  5. L - Z - Antibacterial
  1. Life Science 生命科学
  2. Plant Biotechnology 植物生物技术
  3. Plant Proteomics - Plant Biotechnology
  4. Protein Purification - Plant Proteomics
  5. Additional Affinity Purification - Protein Purification
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfonates/Sulfinates - Sulfur Compounds
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Antibiotics by Application
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Spectrum of Activity
  5. Antibacterial
  6. A - K
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Cytoskeleton and Extracellular Matrix
  5. Extracellular Matrix
  6. Angiogenesis Regulators
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Cytoskeleton and Extracellular Matrix Proteins
  6. Extracellular Matrix
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Xenobiotics and Drug Metabolism
  6. Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Cytoskeleton and Extracellular Matrix Proteins
  6. Extracellular Matrix
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Proteins for Cell Biology
  6. Apoptosis and Cell Cycle Proteins
  7. Apoptosis Inhibitors
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Microtubule/Tubulin  (微管/微管蛋白)

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