5-Fluoroorotic Acid Hydrate 5-氟乳清酸水合物

CAS 207291-81-4 MFCD00150658

化学结构图

207291-81-4
SMILES:

化学属性

Mol. FormulaC5H3FN2O4· xH2O
Mol. Weight174.09 (anhydrous basis)
Melting Point278 °C (dec.)(lit.)
TSCANo

别名和识别编码

Chemical Name5-Fluoroorotic Acid Hydrate
CAS Number207291-81-4
Alfabeta NameFLUOROOROTICACIDMONOHYDRATE 5-
MDL NumberMFCD00150658
Synonym 1,2,3,6-Tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylic acid 2,6-Dihydroxy-5-fluor-pyrimidin-4-carbonsäure 5-Fluor-uracil-4-carbonsäure 4-Pyrimidinecarboxylic acid, 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo- 5-Fluoroorotate 5-Fluoroorotic acid 5-Fluoroorotic acid hydrate 5-Fluorouracil-6-carboxylic acid monohydrate ENT-26398 FO FOA Fluoroorotic acid NSC 31712 Orotic acid, 5-fluoro- Ro 2-9945
PubChem Substance ID24894877
EC Number211-876-0
Reaxys-RN181933
Beilstein Registry Number25(5)8,240
Merck Number4176
Chemical Name Translation5-氟乳清酸水合物
Wiswesser Line NotationT6VMVMJ EVQ FF
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分类

  • {SA} Building Blocks, C4 to C5, Chemical Synthesis, Heterocyclic Building Blocks, Pyrimidines
  • Activity, Biochemicals and Reagents, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Fluorogenic
  • {SNA} Activity, Enzyme Substrates, Fluorogenic, 生化试剂, 酶、抑制剂和底物
  • {SNA} Activity, Biochemicals and Reagents, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Fluorogenic

相关文献及参考

  • Beil. 25 ,IV,1763
  • Merck 14 ,4176
  • Potential antimalarial agent: Antimicrob. Agents Chemother., 40, 914 (1996).
  • Reagent used in the selection of mutant URA3 gene strains of Saccharomyces Cerevisiae: Genetics, 107, 179 (1984); Methods Enzymol., 154, 164 (1987).
  • Structure Index 1 , 409:E:2
  • Winston, F., et al. Genetics 107 , 179, (1984) 摘要

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P312+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Hazard Codes Xn
RTECSUV7800000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Storage condition 0-10 0-10°C 储存温度2-8°C
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ADTEAS Advances in Teratology.  (New York, NY)  V.1-5, 1966-72.
   Discontinued.  Volume(issue)/page/year: 3,181,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 981 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

系列性分类


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