N-(2-(6-Hydroxy-5-Methoxy-1H-Indol-3-Yl)Ethyl)Acetamide N-(2-(6-羟基-5-甲氧基-1H-吲哚-3-基)乙基)乙酰胺

CAS 2208-41-5 MFCD00037971

化学结构图

2208-41-5
SMILES: COc1cc2c(CCNC(C)=O)c[nH]c2cc1O

化学属性

Mol. FormulaC13H16N2O3
Mol. Weight248.31

别名和识别编码

Chemical NameN-(2-(6-Hydroxy-5-Methoxy-1H-Indol-3-Yl)Ethyl)Acetamide
CAS Number2208-41-5
Synonym 6-Hydroxymelatonin 3-(N-Acetylaminoethyl)-6-hydroxy-5-methoxyindole Acetamide, N-(2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl)- N-[2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide
MDL NumberMFCD00037971
PubChem Substance ID1864
Chemical Name TranslationN-(2-(6-羟基-5-甲氧基-1H-吲哚-3-基)乙基)乙酰胺
Beilstein Registry Number0483231
LabNetwork Molecule IDLN01286734
InChIInChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
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分类

  • Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, H, Meatonin - Receptor Agonists, Melatonins, Membrane Protein Biology Tools, Neurobiology, Neuroscience, Pharmacologicals, Proteins and Derivatives
  • {SA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, H, Meatonin - Receptor Agonists, Melatonins, Membrane Protein Biology Tools,
  • {SNA} Bioactive Sm

产品应用

  • A metabolite of Melatonin (M215000).

相关文献及参考

  • Huether, G., et al.: Life Sci., 51, 945
  • Pang, C.S., et al., Comparison of the pharmacological characteristics of 2-[ 125 I]iodomelatonin binding sites in the lung, spleen, brain and kidney of chicken. Biol. Signals 4 , 311, (1995) 摘要
  • Ting, K.N, et al., Studies on the vasoconstrictor action of melatonin and putative melatonin receptor ligands in the tail artery of juvenile Wistar rats. Br. J. Pharmacol. 122 , 1299-1306, (1997) 摘要
  • [1]. Härtter S, et al. Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: a pilot study. Clin Pharmacol Ther. 2001 Jul;70(1):10-6.

安全信息

RTECSAC3607000
WGK Germany3
GHS Symbol
Precautionary statements
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Signal word Warning
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H302 Harmful if swallowed 吞食有害
Hazard Codes Xn
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Storage condition 储存温度-20°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 8 mg/kg
SEX/DURATION            : male 20 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   BIREBV Biology of Reproduction.  (Soc. for the Study of Reproduction, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1969-  Volume(issue)/page/year:
   33,618,1985

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurobiology - Neuroscience
  6. Pharmacologicals - Neurobiology
  7. Melatonins - Pharmacologicals
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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