2-Amino-6-((1R,2S)-1,2-Dihydroxypropyl)Pteridin-4(1H)-One 2-氨基-6-((1R,2S)-1,2-二羟基丙基)蝶啶-4(1H)-酮
CAS 22150-76-1 MFCD00036787
化学结构图
SMILES: C[C@H](O)[C@H](O)c1cnc2nc(N)[nH]c(=O)c2n1
化学属性
| Mol. Formula | C9H11N5O3 |
|---|---|
| Mol. Weight | 237 |
| Density | 1.86 |
| Boiling Point | 590.2 |
| Melting Point | >210 |
别名和识别编码
| Chemical Name | 2-Amino-6-((1R,2S)-1,2-Dihydroxypropyl)Pteridin-4(1H)-One |
|---|---|
| CAS Number | 22150-76-1 |
| Synonym | L-erythro-6-(1,2-Dihydroxypropyl)pterin 6-Biopterin (1’R,2’S)-Biopterin 2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine L-erythro-6-(1,2-Dihydroxypropyl)pterin L-Biopterin; (1'R,2'S)-Biopterin; 2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine (1’R,2’S)-Biopterin L-Biopterin (1R,2S)-Biopterin, 2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine, L-erythro-6-(1,2-Dihydroxypropyl)pterin 2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine Biopterin (1’R,2’S)-Biopterin, 2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine, L-erythro-6-(1,2-Dihydroxypropyl)pterin 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-, (S-(R*,S*))- NSC 339699 (-)-Biopterin |
| MDL Number | MFCD00036787 |
| Beilstein Registry Number | 87860 |
| EC Number | 244-807-8 |
| PubChem Substance ID | 24891654 |
| Chemical Name Translation | 2-氨基-6-((1R,2S)-1,2-二羟基丙基)蝶啶-4(1H)-酮 |
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分类
- Bases & Related Reagents
- {SNA} Cofactors, Oxidation-Reduction, 生化试剂, 酶、抑制剂和底物
- Nucleotides
- Chiral Reagents
- Heterocycles
- Fluorescent Labels & Indicators
- {SNA} Biochemicals and Reagents, Cofactors, Enzymes, Inhibitors, and Substrates, Oxidation-Reduction
产品应用
- A pteridine widely distributed in nature; naturally occurring as the L-erythro-form. Considered as a growth factor for some insects. Fluoresces with a blue color in alkaline solution.
相关文献及参考
- Klatt, P., et al.: J. Biol. Chem., 269, 13861
- [1]. Schallreuter KU, et al. Cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Commun. 1994 Oct 14;204(1):43-8.
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 6,180,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 879 mg/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 6,180,1986
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Parenteral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 10 ug/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 128,147,1984
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