Etanidazole (SR-2508) is a 2-nitroimidazole drug with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

CAS 22668-01-5 MFCD00156108

化学结构图

22668-01-5
SMILES: O=C(Cn1ccnc1[N+](=O)[O-])NCCO

化学属性

Mol. FormulaC7H10N4O4
Mol. Weight214
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameEtanidazole (SR-2508) is a 2-nitroimidazole drug with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
Synonym 1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro- Etanidazole; SR2508; SR 2508; SR-2508 N-(2-Hydroxyethyl)-1-(2-nitro-1-imidazolyl)acetamide N-(2-Hydroxyethyl)-2-nitro-1H-imidazole-1-acetamide NSC 301467 SR 2508
MDL NumberMFCD00156108
PubChem Substance ID24894494
CAS Number22668-01-5
Wiswesser Line NotationT5N CNJ A1VM2Q BNW
Beilstein Registry Number0919296
Chemical Name Translation
FormulaC7H10N4O4
IUPAC NameN-(2-Hydroxyethyl)-2-(2-nitro-1H-imidazol-1-yl)acetamide
InChIKeyWCDWBPCFGJXFJZ-UHFFFAOYSA-N
InChIInChI=1S/C7H10N4O4/c12-4-2-8-6(13)5-10-3-1-9-7(10)11(14)15/h1,3,12H,2,4-5H2,(H,8,13)
Canonical SMILESO=C(NCCO)CN1C=CN=C1[N+]([O-])=O
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分类

  • {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, E, EQ - EZ, Forensic and Veterinary Standards, Neat Compounds, Others

产品应用

  • Etanidazole (SR-2508) is a 2-nitroimidazole drug with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

安全信息

RTECSNI3355000
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RAREAE Radiation Research.  (Academic Press, Inc., 1 E. First St., Duluth,
   MN 55802)  V.1-    1954-  Volume(issue)/page/year: 91,186,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3716 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Musculoskeletal - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 3,153,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4371540

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 80,113,1989

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 1 mmol/L/3D (Continuous)
REFERENCE :
   45OJAG "Radiation Sensitizers: Their Use in the Clinical Management of
   Cancer, Proceedings of the Conference, Key Biscayne, FL, 1979," Brady, L.W.,
   ed., New York, Masson Pub. USA, Inc., 1980  Volume(issue)/page/year:
   -,146,1980

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. E - Alphabetic
  5. EQ - EZ - E
  1. Medical Research Areas
  2. Metabolism
  3. Transferase

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